血管内皮生长因子在心包积液病因鉴别中的价值  

Value of Vascular Endothelial Growth Factor for Etiological Differentiation in Pericardial Effusion

作　　者：曾艳[1] 刘启功[1] 王琳[1] 廖德蓉[1] 程燕子[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院,武汉430030

出　　处：《内科急危重症杂志》2008年第1期27-28,共2页Journal of Critical Care In Internal Medicine

摘　　要：目的:探讨血管内皮生长因子(VEGF)在心包积液病因鉴别中的作用。方法:将渗出性心包积液分成恶性肿瘤组和非肿瘤组,采用双抗体夹心酶联免疫吸附法检测心包积液中VEGF、乳酸脱氢酶(LDH)和腺苷脱氨酶(ADA),并行心包积液常规和细胞学检查,分析比较两组临床特点。结果:恶性心包积液20例,其中肺癌11例,乳腺癌3例,淋巴瘤3例,纵隔肿瘤、直肠癌和黑色素瘤各1例。非恶性心包积液26例,其中结核性16例,结缔组织病7例,甲状腺机能减退2例,射频消融术后1例。恶性心包积液组VEGF水平明显高于非恶性心包积液组(4.53±3.72pg/μlvs1.10±0.74pg/μl,P<0.01),而两组之间LDH、ADA和常规检查无明显差异,ADA、LDH和VEGF之间亦无明显相关性。结论:VEGF在鉴别良恶性心包积液中具有一定的价值。Objective： To investigate the effect of VEGF on etiological differentiation in pericardial effusion. Methods： Patients of exudative pericardial effusion were classified into two groups： malignant tumor group and nonmalignant tumor group. VEGF, LDH and ADA were measured by using sandwich enzyme-linked immunosorbent assay （ELISA）. Routine and cytological examination of pericardial effusion fluid were evaluated, clinical characteristics were analyzed and compared between two groups. Results： Among 20 cases with malignant pericardial effusion, 11 with lung cancer, 3 with breast cancer, 3 with lymphoma and one with mediastinal mass, carcinoma of rectum and melanoma respectively. Among 26 cases with non-malignant pericardial effusion, 16 with tuberculosis, 7 with con nective tissue diseases, 2 with hypothyoidism and one post radiofrequency ablation. Level of VEGF in the malignant precardial effusion group was significantly higher than that in the non-malignant pericardial effusion group（4. 53 ± 3. 72 pg/ul vs 1.10 ± 0. 74 pg/ul,P〈0. 01）,and there were no significant difference of the level of LDH,ADA and the routine examination between two groups. There were no significant correlations among ADA, LDH and VEGF. Conclusion： VEGF has determinate value in the differential diagnosis of pericardial effusion.

关 键 词：心包积液 血管内皮生长因子 乳酸脱氢酶 腺苷脱氨酶 诊断 

分 类 号：R542.12[医药卫生—心血管疾病]