两性霉素B治疗免疫功能低下患者侵袭性真菌感染  

Amphotericin B for Treatment of Invasive Fungal Infections in Immunocompromised Patients

作　　者：肖毅[1] 张义成[1] 孙汉英[1] 黄梅[1] 冉丹[1] 邓金牛[1] 张东华[1] 刘文励[1] 郭静明 周剑峰[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院,武汉430030 [2]湖北省宜昌市中心医院

出　　处：《内科急危重症杂志》2008年第1期29-31,共3页Journal of Critical Care In Internal Medicine

摘　　要：目的:观察国产两性霉素B对免疫功能低下患者侵袭性真菌感染(IFI)的临床疗效及安全性。方法:81例免疫功能低下合并侵袭性真菌感染患者使用普通两性霉素B,剂量为5～50mg/d,用药7～66d,平均24.5d,每位患者平均累积剂量605mg。结果:两性霉素B临床总有效率为75.7%,真菌清除率为66.7%,不良反应发生率寒战、发热58.0%,低血钾44.4%,消化道18.5%,肾功能损害14.8%。结论:国产两性霉素B抗真菌谱较广,疗效好,但须合理用药,定期监测肝肾功能、血钾水平。Objective：To observe the therapeutic effect and side effects of conventional amphotericin B for invasive fungal infections （IFI） in immunocompromised patients. Methods： Eighty-one immunocompromised patients with IFI were given conventional amphotericin B, 5- 50mg/d for 7 to 66 days （average 24. 5 days, total average dose 605rag for each patients）. Results： Clinical efficacy rate of amphotericin B was 75. 7%, fungal elimination rate was 66. 7% ,and adverse reaction were chilis 58. 0%, hypokalemia 44. 4%, gastrointestinal symptoms 18. 5%, kidney damage 14. 8 %. Conclusion： Conventional amphotericin B is effective and less expensive in treatment of IFI, but hepatic and renal functions and electrolyte balance should be monitored.

关 键 词：两性霉素B 免疫功能低下 侵袭性真菌感染 

分 类 号：R519[医药卫生—内科学]