母血浆IL-10水平与正常妊娠及早产关系研究  

Relationship between Maternal Plasma IL-10 Levels in Normal Pregnancy and Preterm Delivery

作　　者：陈英[1] 杨祖菁[2] 

机构地区：[1]上海中医药大学附属普陀医院,上海200062 [2]上海交通大学医学院附属新华医院,上海200092

出　　处：《实用妇产科杂志》2008年第1期27-29,共3页Journal of Practical Obstetrics and Gynecology

摘　　要：目的：研究孕妇血浆白细胞介素-10（IL-10）在孕晚期（孕28～36^＋6周之间）的变化情况，探讨IL—10与早产之间的关系。方法：采用酶联免疫吸附法对51例研究组孕妇（包括29例先兆早产和22例早产孕妇）和57例对照组孕妇（妊娠过程顺利并足月分娩）相应孕周时的血浆IL—10进行检测。结果：孕妇血浆IL—10在孕晚期呈逐渐下降趋势，但其变化不显著（P〉0.05）；研究组孕妇血浆IL—10明显低于对照组（P〈0.05）；合并亚临床绒毛膜羊膜炎时，早产孕妇又明显高于先兆早产者。结论：IL-10在正常妊娠的维持中起重要作用。Objective：To investigate the change of maternal plasma interleukin - 10（ IL- 10） levels during 28 - 37 weeks＇ gestation, and to study the relationship between IL- 10 and inevitable preterm delivery.Methods： Plasma levels of IL- 10 were measured by enzyme- linked immunosorbent assay. 51 cases ware recruited in study group, including 29 cases of threatened preterm labor and 22 cases of preterm delivery; 57 cases in control group with term delivery. Results： During 28- 37 weeks＇ gestation, maternal plasma IL- 10 concentration was gently descending （ P〉0.05）. The levels of plasma IL- 10 of study group ware significantly lower than that of controlled women （ P〈 0.05）. In women with subclinical chorioamnionitis, level of IL- 10 in preterm delivery were significantly higher than that of threatened preterm labor （P〈0.05） .Conclusions： Maternal plasma IL- 10 may play an important role in maintaining normal pregnancy.

关 键 词：白细胞介素-10 早产 先兆早产 亚临床绒毛膜羊膜炎 

分 类 号：R714.21[医药卫生—妇产科学]