内质网膜上的转运使者——易位子相关蛋白(TRAP)  

The Current Progress in Translocon-associated Protein

作　　者：吴涛[1] 张耀洲[1] 

机构地区：[1]浙江理工大学生物化学研究所,浙江杭州310018

出　　处：《中国生物化学与分子生物学报》2008年第2期95-100,共6页Chinese Journal of Biochemistry and Molecular Biology

基　　金：国家重点基础研究发展规划(973计划;No.2005CB121006);国家科技支撑计划项目(No.2006BAI01B04);国家自然科学基金(No.30670095);浙江省自然基金重点项目(No.Z204267)~~

摘　　要：内质网膜蛋白在参与信号序列的识别、新生肽链的修饰、转运通道的形成等生理过程中发挥重要作用.易位子相关蛋白(translocon-associated protein,TRAP)是广泛存在于高等真核生物中的一种膜蛋白,其作为信号序列的受体蛋白位于内质网膜上.该蛋白能选择性地识别信号序列,并与Sec61相互作用形成一个以Sec61为核心、TRAP侧向延伸的椭圆状转运通道,从而靶向新生肽链进入内质网腔.近来研究发现,TRAP与蛋白质构象病、神经退行性疾病、肿瘤转移等疾病的发病机制有关.本文将对TRAP各个亚基的最新研究及其功能作一综述.Endoplasmic reticulum （ER） membrane proteins play a crucial role in physiological processes such as the recognition of signal sequence, the modification of nascent peptide and the form of translocation form a translocation channel. Sec61 serves as a core, while TRAP forms a lateral extension to direct the nascent peptides to be inserted into the ER lumen. TRAP has a tripartite architecture with a prominent luminal domain that connects to Sec61 channel by two stalk-like characteristics. Recently, increasing number of studies demonstrated that TRAP may be related to the pathogenesis of protein conformation diseases, neurodegenerative disorders, ultraviolet-induced melanomagenesis and metastasis. This review primarily focuses on the latest study of the TRAP subunits and their functions.

关 键 词：易位子相关蛋白 易位子 Sec61 内质网膜 信号序列 

分 类 号：Q7[生物学—分子生物学]