A型激酶锚定蛋白及其信号复合物结构与功能  

Structure and Function of A-kinase Anchoring Proteins and Their Signaling Complexes

作　　者：王默进[1] 王玲[1] 周总光[1] 

机构地区：[1]四川大学华西医院消化外科研究室生物治疗国家重点实验室,成都610041

出　　处：《中国生物化学与分子生物学报》2008年第2期101-106,共6页Chinese Journal of Biochemistry and Molecular Biology

基　　金：国家自然科学基金(No.30571811和30400434);美国中华医学基金(No.CMB96636)~~

摘　　要：A型激酶锚定蛋白(A-kinase anchoring proteins,AKAPs)是一类结构不同而功能相关的蛋白家族,其主要功能是将cAMP依赖性蛋白激酶A(PKA)锚定于特定的亚细胞结构.PKA是第二信使cAMP的主要效应器,而AKAPs在靶向定位和调节PKA介导的磷酸化事件方面扮演重要角色.AKAPs更为重要的功能是与多种信号分子形成信号复合物,从时间和空间上整合cAMP-PKA和其他信号途径.本文将对AKAPs及其信号复合物的结构特点和参与细胞信号转导的功能机制及其研究现状进行概述.A-kinase anchoring proteins （AKAPs） are a family of structurally diverse but functionally related proteins that anchor cAMP dependent protein kinase A （PKA） to specific subcellular sites. As PKA is the primary effector of the second messenger cAMP, AKAPs play an important role in the targeting and regulation of PKA-mediated phosphorylation events. A more important role of AKAPs is their capacity to form multisignaling molecule complexes that integrate spatiotemporally cAMP-PKA signaling with other signaling pathways. This review will focus on the structural features and functional mechanism which AKAPs and AKAP signaling complexes involved in cell signal transduction, and the situation of current research of AKAPs.

关 键 词：A型激酶锚定蛋白 A型激酶锚定蛋白信号复合物 结构特点 生物功能 

分 类 号：Q71[生物学—分子生物学]