合成meso-四(对羟基苯基)卟啉的工艺改进  

Process Improvement on the Synthesis of meso-Tetra(4-hydroxylphenyl)porphyrin

作　　者：章艳[1] 高保娇[1] 

机构地区：[1]中北大学化学工程系,山西太原030051

出　　处：《合成化学》2008年第1期86-88,92,共4页Chinese Journal of Synthetic Chemistry

基　　金：山西省自然科学基金资助项目(20040402JJ)

摘　　要：改进Adler法合成了meso-四(对羟基苯基)卟啉(THPP),其结构经UV-Vis,1H NMR和IR表征。合成THPP较适宜的反应条件为:对羟基苯甲醛50 mmol,吡咯50 mmol,丙酸120 mL,DMSO 6 mL,回流反应120min,收率35%。meso-5,10,15,20-Tetra（4-hydroxylphenyl）porphyrin （THPP） was synthesized by improved Adler＇ s method. The structure was confirmed by UV-Vis, ^1H NMR and IR. The appropriate reaction conditions at reflux for 120 min were as follows： p-hydroxy-benzaldehyde was 50 mmol; pyrrole was 50 mmol; propionic acid was 120 mL; dimethyl sulfoxide was 6 mL. The yield of THPP can reach up to 35% under the reaction conditions.

关 键 词：卟啉 合成 工艺改进 

分 类 号：O626[理学—有机化学]