阿霉素纳米粒的制备与模拟体外释放行为  

A study on the preparation and in vitro release models of doxorubicin-nanoparticles

作　　者：吕凤娇[1] 陈晓耕 许小平[1] 

机构地区：[1]福州大学化学化工学院,福建福州350002 [2]福建省省立医院,福建福州350000

出　　处：《计算机与应用化学》2008年第2期148-150,共3页Computers and Applied Chemistry

基　　金：福建省科技厅国际合作项目(2005I010，2001Z046)

摘　　要：制备以聚乙烯吡咯烷酮为载体的阿霉素纳米粒,研究纳米粒在生理盐水中的释放行为,并采用不同数学模型模拟。结果表明,制备的阿霉素纳米粒粒径小,球形度好;体外释放结果表明阿霉素纳米粒具有缓释特性,且双相动力学方程能模拟阿霉素纳米粒在生理盐水中的释放行为。Doxorubicin-loaded nanoparticles, using doxorubicin （ADM）as model drug, polyvinylpyrrolidone （PVP） as matrix material, were prepared in this paper. From the observation of SEM, the nanoparticles exhibited a spherical shape. Dialysis method was used to test the property of nanoparticles in vitro release. Several mathematical models of drug release, such as zero order equation, first order equation, Higuchi and double exponential diphase kinetics equation, were used to fit the vitro release of NP. The double exponential diphase kinetics equation included a concussion phase and a slow-release phase. The simulation results showed that it could fit better drug release of nanoparticles in Physiological Saline.

关 键 词：纳米粒 体外释放 模拟 

分 类 号：TQ46[化学工程—制药化工]