急性冠脉综合征焦虑抑郁与超敏C-反应蛋白关系的研究  

Relationship of hs-CRP with the state of anxiety and depression in patients with acute coronary syndrome

作　　者：李美婧[1] 马文林[1] 徐颖[1] 张俊蒙[1] 胡大一[1] 

机构地区：[1]同济大学医学院附属同济医院心肺血管中心,上海200092

出　　处：《中国实用内科杂志》2008年第3期187-189,共3页Chinese Journal of Practical Internal Medicine

摘　　要：目的研究急性冠脉综合征(ACS)患者情绪焦虑抑郁状态与超敏C-反应蛋白(hs-CRP)的关系。方法连续收集2006年2月至2007年10月入住同济大学医学院附属同济医院、上海市第十人民医院、东方医院、上海市闸北区中心医院和上海市市东医院5所医院心血管内科病房的647例ACS患者,于入院时抽取外周静脉血,监测其发病36h以内血浆hs-CRP;患者入院7d内完成标准化问卷调查表《医院情绪抑郁及焦虑量表》(HADS)并计分,记录年龄、性别、冠心病危险因子及相关临床数据。结果焦虑组患者血浆hs-CRP显著低于非焦虑非抑郁组[(10.43±3.55)mg/L对(13.19±4.90)mg/L,P<0.05],抑郁组患者血浆hs-CRP显著高于非焦虑非抑郁组[(25.41±7.07)mg/L对(13.19±4.90)mg/L,P<0.05],焦虑抑郁共病组患者与非焦虑非抑郁组患者血浆hs-CRP差异无统计学意义[(14.62±5.01)mg/L对(13.19±4.90)mg/L,P>0.05]。结论ACS合并情绪抑郁程度与患者体内炎性反应活跃有关;而焦虑情绪与炎症反应活性之间无正相关关系。Objective To explore the relationship of the presence and severity of anxiety and depression with the increased inflammatory activity, as marked by the serum levels of high sensitivity C reactive protein（hs-CRP） after acute coronary syndrome（ACS）. Methods Serum hs-CRP levels were measured in 647 ACS patients within 36 hours after onset of event. Depression and anxiety were evaluated by serf-reporting standardized questionnaire, using a validated Chinese version of Hospital Anxiety and Depression Scale （HADS） （ 14 items） within 7 days. Results In ACS patients, serum levels of hs-CRP（rag/L） were lower in those with anxiety than those in control grouP[ （10. 43 ± 3. 55 ）mg/L vs （13. 19 ± 4.90）rag/L, P 〈 0.05 ]. However, serum levels of hs-CRP were higher in those with depression than control ones [（ 25.41 ± 7.07 ） mg/L vs （ 13.19 ± 4. 90 ） mg/L, P 〈 0. 05 ] ; the difference of serum levels of hs-CRP between those with both anxiety and depression and those who have neither anxiety nor depression was not significant[ （ 14. 62 ± 5.01 ） mg/L vs （ 13.19 ±4.90） mg/L,P 〉0. 05]. Conclusion Presence and severity of depression is associated with increased activity of inflammation in patients with ACS;however,anxiety does not have such an association with inflammation in patients with ACS.

关 键 词：急性冠脉综合征 超敏C-反应蛋白 焦虑 抑郁 

分 类 号：R5[医药卫生—内科学]