肾综合征出血热并发肝损害453例临床分析  

Clinical analysis of 453 hemorrhagic fever with renal syndrome patients complicated with liver damage

作　　者：王九平[1] 王平忠[1] 李军[1] 魏欣[1] 王临旭[1] 王雅格[1] 张颖[1] 何文革[1] 

机构地区：[1]第四军医大学唐都医院全军感染病诊疗中心,西安710038

出　　处：《肝脏》2008年第1期14-16,共3页Chinese Hepatology

摘　　要：目的探讨肾综合征出血热(HFRS)合并肝损害的临床特点及其规律性。方法对453例各期HFRS患者的肝功能及相关指标进行回顾性分析。结果各期HFRS患者均伴有肝损害,转氨酶轻度增高居多.γ-谷氨酰转肽酶(GGT)早期轻到中度升高,总胆红素仅轻度升高,碱性磷酸酶变化不明显。轻型、中型肾综合征出血热并发肝损害较少,重型、危重型多并发肝损害。结论肾综合征出血热早期即可并发肝损害,发生率较高,以转氨酶及GGT轻至中度增高为特征。不同类型HFRS患者肝损害程度与临床表现成正相关。肾综合征出血热病程中动态观察肝功能的变化有助于判断病情和预后。Objective To investigate the clinical characteristics and regularities of liver damage in patients of hemorrhagic fever with renal syndrome （HFRS）. Methods A retrospective analysis of liver function test was taken in 453 patients with HFRS. Results Liver damage could be seen in different stages of HFRS. Most of the HFRS patients with liver damage presented with mild increase of alanine aminotransferase （ALT） and aspartate aminotransferase （AST） （92. 56%）, and mild increase of total bilirubin levels （94. 15%）. While the level of γ-glutamyltransferase （GGT） increased mildly to moderately, and the level of alkaline phosphatase did not visible change obviously. Conclusion Liver damage is common in patients with HFRS and can occur in different stages. It is characterized by the mild to medium increase of ALT, AST and GGT levels. The degree of liver damage is related to the severity of HFRS. Monitoring the liver function indexes is helpful for evaluating the progression and prognosis of HFRS.

关 键 词：肾综合征出血热 肝损害 临床特点 

分 类 号：R512.8[医药卫生—内科学] R575[医药卫生—临床医学]