不同剂量氮斯汀及联合西咪替丁治疗慢性荨麻疹疗效观察  

Different dosages of azelastine and in combination of cimetidine in the treatment of chronic urticaria

作　　者：吴绍熙[1] 郭宁如[1] 陈佳[1] 孙建方[1] 

机构地区：[1]中国医学科学院、中国协和医科大学皮肤病研究所,江苏南京210042

出　　处：《临床皮肤科杂志》2008年第3期194-196,共3页Journal of Clinical Dermatology

摘　　要：目的:对比不同剂量氮斯汀及联合西咪替丁治疗慢性荨麻疹的疗效及不良反应。方法:采用随机入组开放观察同样疗程不同剂量氮斯汀(A、B两组)及联合西咪替丁(B+C组)治疗慢性荨麻疹的疗效及不良反应。A组患者采用氮斯汀4mg/d治疗;B组患者采用氮斯汀2mg/d治疗;B+C组患者采用氮斯汀2mg/d联合西咪替丁400mg/d治疗。3组患者均在28d时观察疗效及不良反应。结果:A组显效27例(81.8%),良效4例(12.1%),微效2例(6.1%);B组显效21例(61.8%),良效6例(17.6%),微效7例(2.06%);B+C组显效26例(78.8%),良效3例(9.1%),微效4例(12.1%)。A组出现口干1例,困倦2例;B组出现口干3例,头昏、困倦1例;B+C组出现困倦3例,口干1例。均不影响疗效。结论:A组及B+C组患者的疗效相似,且高于B组,差异有统计学意义(P<0.05)。Objective： To evaluate effects and side effects in different dosages of azelastine and in combination with cimeti dine for treatment of chronic urticaria. Methods： By open randomized grouping to evaluate the effects and side effects of 4 mg/d （A）, 2 mg/d （B） and 2 mg/d azelastine combined with 400 mg/d cimetidine （B＋C） P.O. for 28 d in treating chronic urticaria in each group. Results： In group A, there were 27/33 （81.8%） marked improved, while in group B, there were 21134 （61.8%） marked improved, χ^2=3.31, P〈 0.05. In group B＋C, there were 26/33 （78.8%） marked improved, no significant difference with group A. There were no difference in side effects of these 3 groups. Conclusion： There is no difference in side effects of A, B and B＋C groups, hut the effects in group A and group B are different （P〈 0.05）.

关 键 词：荨麻疹 慢性 氮[艹卓]斯汀 西咪替丁 

分 类 号：R758.24[医药卫生—皮肤病学与性病学]