产后康膏的质量标准研究  

Study on the Quality Standard for Chanhoukang Paste

作　　者：宋娟[1] 潘金火[1] 

机构地区：[1]南京中医药大学药学院,江苏南京210046

出　　处：《时珍国医国药》2008年第2期366-367,共2页Lishizhen Medicine and Materia Medica Research

摘　　要：目的建立产后康膏的质量标准。方法采用薄层色谱法对处方中陈皮、黄芪、甘草进行鉴别；用高效液相法测定制剂中芍药苷的含量，采用Lichrospher-C18色谱柱（4．6mm×200mm，5μm），流动相为水-乙腈（87：13），流速1．0ml／min；柱温30℃；检测波长230nm；进样量10μl。结果薄层色谱专属性强；芍药苷的线性范围为0．536～2．144μg，r=0．9995，平均加样回收率为97．96％，RSD为1．71％（n=6）。结论该方法简便、准确，重复性好，可作为产后康膏的质量控制标准。Objective To establish the quality standard for Chanhoukang Paste. Methods Rericarpium Cirri Reticulatae, Radix Astragali, Radix et Rhizoma Salviae and Radix Glycyrrhizae in this prescription were identified by TLC. The content of paeoniflorin was determined by HPLC. The column of Lichrospher- AQ -C18 （4.6 mm× 200 mm,5μm）was used. The mobile phase was Acetonitrile -Water（ 13：87）, at the flow of 1.0 ml·min^-1. The column temperature was 30℃ , and peaks were detected at 230 nm. Results The study on the quality control showed that the characteristic of identification by TLC was distinct and highly specific. The linear range of naringin was 0. 536 - 2. 144 μg, r = 0. 9995, the average recovery was 97.96%, RSD = 1.71% （ n = 6 ）. Conduslon The method is easy, accurate and reproducible. It can be used effectively for the quality control of this preparation.

关 键 词：产后康膏 芍药苷 陈皮 黄芪 甘草 质量标准 

分 类 号：R284.1[医药卫生—中药学]