蛇床子素对小鼠免疫药理作用的研究  

Effects of Osthole on Immunopharmacology in Mice

作　　者：刘桦[1] 蒋韵[1] 韩英[2] 

机构地区：[1]南京铁道医学院免疫药理组,210009 [2]南京药物研究所植化室

出　　处：《中草药》1997年第9期543-545,共3页Chinese Traditional and Herbal Drugs

摘　　要：通过小鼠碳粒廓清、迟发性超敏反应、血清溶血素含量测定等实验观察，初步探讨蛇床子素对免疫系统的影响。结果显示，蛇床子素能增强小鼠网状内皮细胞的吞噬功能，腹腔连续4d给予0．2mg／kg的蛇床子素能显著增加碳粒廓清指数（P＜0．05）及吞噬指数（P＜0．01），对小鼠迟发性超敏反应有明显的抑制作用，对小鼠血清溶血素含量的影响与对照组没有显著性差异。Osthole was one of the active components isolated from the fruit of Chidium monnier (L. ) Cusson. Its immunopharmacological activities were studied with results which showed that osthole markedly increased the clearance rate of iv charcoal particles and the weight of spleen in mice. A study on the effect on the cellular and humoral immune response showed that it remarkably inhibited delayed type hypersensitivity,but the pro duction of serum hemolysin was not changed. These results suggested that osthole had immunopharma cological activities

关 键 词：蛇床子素 中药 药理 免疫药理学 

分 类 号：R285.5[医药卫生—中药学]