绿原酸在兔体内对CA4P药动学的影响  

Effects of CHA on Pharmacokinetics of CA4P in Healthy Rabbits

作　　者：刘静[1] 徐小平[1] 张洁[1] 田晨煦[1] 

机构地区：[1]四川大学华西药学院,成都610041

出　　处：《中国药学杂志》2008年第4期297-299,共3页Chinese Pharmaceutical Journal

摘　　要：目的研究绿原酸对CA4P在兔体内的药动学影响。方法采用RP-HPLC测定8只健康家兔单用CA4P及合用绿原酸后CA4的血药浓度,药-时数据经DAS统计软件拟合处理,对2种给药方式的主要药动学参数进行比较。结果与单用CA4P时相比,合用绿原酸后,CA4在血浆内的清除率(CL)、药-时曲线下面积(AUC)、血药浓度峰值(ρmax)、表观分布容积(Vd)、平均滞留时间(MRT)等药动学参数无显著变化(P>0·05),仅消除半衰期(t1/2ke)有所延长(P<0·05)。结论高剂量绿原酸与CA4P合并用药后可延长CA4的消除半衰期。OBJECTIVE To study the pharmacokinetic effects of CHA on CA4P in rabbits. METHODS A single dose of CA4P or CA4P in combination with CHA was respectively given to 8 rabbits in an open randomized cross-over way. CA4 concentrations in plasma were assayed by RP-HPLC method. Concentration-time curves were simulated by DAS program, and the pharmaeokinetie parameters between the group treated with CA4P alone and the group with combined treatment were compared. RESULTS Compared with the group treated with CA4P alone, t1/2 increased significantly in the group with combined treatment. There was no significant difference in CL, Vd MRT,ρmax and AUC between CA4P alone and combined treatment group, CONCLUSION The combined use of high dose CHA and CA4P leads to anincrease in the t1/2 OF CA4.

关 键 词：绿原酸 CA4P 高效液相色谱法 药动学 

分 类 号：R969[医药卫生—药理学]