云南不明原因心源性猝死心肌酶学研究  

Research of Cardiac Muscle Enzyme of Unexpected Sudden Cardiac Deaths in Yunnan,China

作　　者：王跃兵[1] 黄文丽[1] 杨林[1] 李兆祥[1] 赵溯[1] 马琳[1] 王安伟[1] 李加国[1] 申涛[2] 任金马[2] 愈梦越[3] 陆荣安 祖家香 张从和 曾光[2] 

机构地区：[1]云南省地方病防治所 [2]中国疾病预防控制中心 [3]中国医学科学院北京阜外心血管病医院 [4]云南省大姚县疾病预防控制中心

出　　处：《地方病通报》2008年第1期1-4,共4页Endemic Diseases Bulletin

基　　金：云南省科技厅攻关项目(2004NG13);卫生部科学研究基金项目(WKJ-2003-01-05);科技部攻关项目(2003BA712A11-01);大理州科学研究基金项目

摘　　要：目的探索发病村村民与周围自然村村民的心肌酶在本病流行期和非流行期是否存在差异,为深入开展具有针对性的病因研究提供线索。方法选取发病村村民24人和3个对照村每村30人作为研究对象,在流行期和非流行期分别采集研究人群的血清作心肌酶、肝、肾功等检测。结果发病村和对照村人群的4个心肌酶指标在各次检测中异常率均较高,依次是CK-MB、CK、HBDH、LDH。发病村异常率高于对照村;CK-MB/CK均大于5%;CK-MB最高值为上限值5倍,CK为4倍,HBDH为2.36倍,LDH为1.5倍;发病村人群非流行期LDH,HBDH较流行期明显下降。结论发病村村民和同在一山系的对照村村民的4种心肌酶指标异常率在流行期和非流行期均较高,提示该地区(山系)自然环境中可能存在某些致心肌酶增高的危险因素。Objective In order to master the difference of the cardiac muscle enzyme in epidemic and non - epidemic area of unexpected sudden cardiac Twentyfour villagers from the epidemic villages, death in Dayao County in Yunnan Provence. Methods and total 90 villagers from 3 control villages were selected to detect the cardiac muscle enzyme, hepatic and renal function in the period of endemic and non - endemic, respectively. Results Four indices of cardiac muscle enzyme were high in the abnormal detection. They were CK - MB, CK, HBDH and LDH in turn. The abnormal rate was higher in the epidemic area than in the control villages. The highest CK - MB was 5 times of upper limit with the CK of 4 times, the HBDH of 2.36 times and the LDH of 1.5 times. The LDH and HBDH of villagers in the epidemic villages decreased obviously in the epidemic period than in the non- epidemic period. Conclusions There may be risk factors that lead to cardiac muscle enzyme hoist in the environment, because the abnormal rate of 4 cardiac muscle enzymes of villagers in epidemic villages was high both in epidemic and non - epidemic period compared the control villagers.

关 键 词：心肌酶 不明原因心源性猝死 大姚 云南 

分 类 号：R541[医药卫生—心血管疾病] R181.23[医药卫生—内科学]