清白胶囊对急性血瘀模型大鼠血液流变学及血栓形成的影响  

Effects of Qingbai capsule on hemorheological changes and formation of extracorporeal thrombus in rats with acute blood stasis

作　　者：尹政[1] 胡冠宇[1] 夏醒醒[1] 陈勤[1] 

机构地区：[1]安徽大学生命科学学院,安徽省中药研究与开发重点实验室,合肥230039

出　　处：《中国新药杂志》2008年第3期207-209,218,共4页Chinese Journal of New Drugs

基　　金：安徽省合肥市科技计划2006年重点项目(2006-25)

摘　　要：目的:研究清白胶囊对急性血瘀证大鼠血液流变学和体外血栓形成的影响。方法:运用皮下注射大剂量盐酸肾上腺素复加冰水冷浴建立大鼠急性血瘀模型,利用此模型观察清白胶囊对模型大鼠血液流变学指标和体外血栓形成的影响。结果:清白胶囊(6.0,3.0,1.5 g.kg-1)灌胃,连续给药14 d,均能明显降低全血黏度(200,30,5,1 s-1切变率)、全血相对黏度(200,1 s-1切变率)、血浆黏度、血细胞比容、纤维蛋白原含量、血小板黏附值以及黏附率等血液流变指标;显著降低体外血栓的长度和重量(与模型组比较P<0.05或0.01)。结论:清白胶囊能有效改善急性血瘀证大鼠血液流变异常,具有抗血小板黏附和抗血栓形成的作用。Objective： To investigate the effects of Qingbai capsule （QBC） on hemorheological changes and extracorporeal thrombus formation in a rat model of acute blood stasis. Methods： The acute blood stasis was induced by subcutaneous injection of large dose of adrenaline hydrochloride and ice-water socking in rats. Rats were treated with oral QBC daily for 14 d. Then, the hemorheological parameters and extracorporeal thrombus formation were observed for evaluating the effects of QBC. Results： QBC （6.0, 3.0 and 1.5 g·kg^-1） obviously decreased the whole blood viscosity at 200, 30, 5 and 1 s^-1 shear rate and the relative viscosity at 200 and 1 s^-1 shear rate. QBC significantly reduced the plasma viscosity, the hematocrit （HCT）, the content of fibrinogen （FIB） and the platelet adhesiveness; also obviously shortened the length, wet and dry weights of thrombus （P 〈0.05 and 0.01, as compared with vehicle）. Conclusion： QBC effectively ameliorates the hemorheological changes, and inhibits platelet adhesion and thrombus formation.

关 键 词：清白胶囊 急性血瘀模型 血液流变学 血栓形成 

分 类 号：R285.5[医药卫生—中药学] R356.4[医药卫生—中医学]