荜澄茄、干姜、辛夷挥发油对雪上一枝蒿总碱体外经皮渗透的影响  

Effects of volatile oil of Fructus Litseae,Rhizoma Zingiberis and Flos Magnoliae on percutaneous penetration of the total alkali of shortstalk monkshood roots through mouse skin in vitro

作　　者：李艳杰[1] 白一岑[1] 马云淑[1] 

机构地区：[1]云南中医学院中药学院,昆明650200

出　　处：《中国新药杂志》2008年第4期310-313,共4页Chinese Journal of New Drugs

基　　金：国家自然科学基金项目(30560187)

摘　　要：目的:考察荜澄茄、干姜、辛夷挥发油对雪上一枝蒿总碱经皮渗透的影响。方法:采用改良Franz扩散池法,以小鼠皮肤为透皮屏障,用高效液相色谱法(HPLC)测定雪上一枝蒿总碱中甲素的累积渗透量,并以氮酮为对照,考察不同浓度的荜澄茄、干姜、辛夷3种挥发油对雪上一枝蒿总碱的促渗效果。结果:5%荜澄茄、7%干姜、7%辛夷挥发油与3%氮酮的促渗效果最好,渗透系数(×10-3cm.h-1)分别为55.81,38.28,35.23,34.46;与无促渗剂组相比,促渗倍数分别为1.73,1.18,1.09,1.06倍。结论:5%荜澄茄、7%干姜、7%辛夷挥发油均能促进雪上一枝蒿总碱的经皮渗透(P<0.05)。Objective ： To investigate the effects of the volatile oil of Fructus Litseae （ FL）, Rhizoma Zingiberis（RZ） and Flos Magnoliae（FM） on percutaneous penetration of the total alkali of shortstalk monkshood root through mouse skin in vitro. Methods：The effects of these 3 kinds of volatile oil and azone on the percutaneous penetration of the total alkali in shortstalk monkshood roots were observed with an improved Franz diffusion cells. The cumulative amount of bullatine A penetrating into mouse skin in vitro was determined by HPLC. Results：5% volatile oil of FL,7 % volatile oil RZ and FM and 3 % azone were optium concentrations, the penetration rates were 55.81 , 38.28,35.23,34.46×10^-3cm·h^-1 , respectively. Compared with the group without penetration enhancers, the enhancement ratios were 1.73,1. 18,1.09,1.06, respectively. Concluslon：The volatile oil of FL, RZ and FM enhance the permeation of the total alkali of shortstalk monkshood roots through mouse skin effectively （P〈0.05）.

关 键 词：促渗剂 雪上一枝蒿总碱 挥发油 荜澄茄 干姜 辛夷 

分 类 号：R943.43[医药卫生—药剂学] R286.1[医药卫生—药学]