新型布氏菌素的研制  

The Research and Produce of a New type Brucellin

作　　者：郝宗宇 李恪梅 高玉真[1,2] 黄建 张爱梅 吕家锐[1,2] 邓文斌 

机构地区：[1]河南省地方病防治研究所布氏菌病研究室 [2]中国药品生物制品检定所

出　　处：《河南医学研究》1997年第4期298-300,共3页Henan Medical Research

基　　金：河南省科委资助课题

摘　　要：目的：解决人用布氏菌素的非特异反应问题。方法：用三氯醋酸和硫酸铵从布氏菌菌液中制备了富含蛋白（９５％以上）的布氏菌素。结果：经多次动物试验证明，该菌素具有良好的变态反应原性，其特异性和敏感性与参考标准品完全一致。结论：实验研究结果显示，该制品为纯度高、质量好、易标化的新型布氏菌病诊断制剂。Objective: In order to solve the nonspecific reaction problem of Brucellin for human beings. Methods: We have prepared Brucellin rich in proteins (exceeding ninty five percent)with trichloracetic acid and ammonium sulphate from Brucella cultures. Results: Repeatedly animal experiments proved that these Brucellin have good original metamorphotic reaction.The specificity and sensibility is consistent with the standardized product.Conclusion: The experiment results indicated that the Brucellin is a new type high purity,good quality and easy standardization diagnostic preparation for Brucellosis.

关 键 词：布鲁氏菌病 布氏菌素 研制 

分 类 号：R516.703[医药卫生—内科学] R392－33[医药卫生—临床医学]