均匀设计法优选玄丹巴布剂基质配方  

Optimization of the matrix formulation of Xuandan cataplasmby uniform design

作　　者：孟舒 关艳敏 刘丹华 杨丹 刘婷立 

机构地区：[1]辽宁省计划生育研究院,辽宁沈阳110031 [2]辽宁成大方圆医药连锁有限公司,辽宁沈阳110000

出　　处：《广东药学院学报》2007年第6期625-627,共3页Academic Journal of Guangdong College of Pharmacy

基　　金：辽宁省科技厅科技攻关项目(2004225003)

摘　　要：目的对玄丹巴布剂的基质配方进行优选。方法通过均匀设计法,以影响巴布剂物理性状的几种主要辅料为考察因素,以各种辅料不同用量为考察水平,以成型巴布剂基质的剥离强度、持黏力为考察指标,通过对数据的分析,优选出最佳的基质配方。结果基质最佳质量比为卡波姆:PANA_1:PANA_2:甘油:柠檬酸:AlCl_3=1.5:2.5:2.7:11:0.36:0.5。结论由此配方制得的巴布剂贴敷于皮肤上,粘贴紧密,撕下后无基质残留于皮肤,质量较好。Objective To optimize the matrix formulation of Xuandan cataplasm.Methods Matrix agents were optimized based on their physicochemical indices including peeling strength and viscosity.The matrix components of cataplasm were optimized by uniform design.Results The optimal matrix formulation was carbopol 940：PANA1：PANA2：glycerin：citric acid：AlCl3=1.5：2.5：2.7：11：0.36： 0.5.Conclusion The optimized cataplasm has good viscosity and high adhesive strength.

关 键 词：均匀设计 玄丹 巴布剂 基质 

分 类 号：R283[医药卫生—中药学]