踝肱指数在2型糖尿病外周动脉疾病中的应用  

An Application Study of Ankle Brachial Index in Type 2 Diabetes Mellitus with Peripheral Arterial Disease in Lower Extremities

作　　者：张红梅[1] 陈璐璐[1] 刘佩文[2] 吴朝虹[2] 王丽[3] 张静[2] 陈丹[2] 易兰兰[2] 

机构地区：[1]华中科技大学同济医学院附属协和医院内分泌科,湖北省武汉市430022 [2]湖北省新华医院内分泌科,湖北省武汉市430015 [3]湖北省新华医院检验科,湖北省武汉市430015

出　　处：《中国动脉硬化杂志》2007年第11期847-850,共4页Chinese Journal of Arteriosclerosis

摘　　要：目的评价踝肱指数在2型糖尿病伴外周动脉疾病诊断中的意义。方法486例2型糖尿病患者按踝肱指数<0.9和≥0.9分为外周动脉疾病组和不伴外周动脉疾病组,比较两组的临床特征,并分析与踝肱指数相关的因素,确定2型糖尿病伴外周动脉疾病的危险因素。结果外周动脉疾病组平均年龄、糖尿病病程和低密度脂蛋白胆固醇水平显著高于不伴外周动脉疾病组(分别为62.09±10.53岁比56.77±9.83岁、86.90±51.94月比57.91±57.64月及3.07±1.01mmol/L比2.71±0.98mmol/L;P<0.05或P<0.01),踝肱指数显著低于不伴外周动脉疾病组(0.77±0.15比1.08±0.15,P<0.01)。Pearson相关分析显示,踝肱指数与年龄(r=-0.159,P=0.01)和总胆固醇(r=-0.161,P=0.01)负相关。Logistic回归分析显示,年龄、病程、收缩压和低密度脂蛋白胆固醇是2型糖尿病伴外周动脉疾病的危险因素,腰臀比是其发病的保护因素。结论踝肱指数是筛查2型糖尿病外周动脉疾病的简单易行又可靠的指标,年龄、病程、收缩压、低密度脂蛋白胆固醇是2型糖尿病患者踝肱指数降低的危险因素。Aim To assess the significance of ankle brachial index（ABI） in the type 2 diabetes（T2DM） with peripheral arterial disease（PAD） in lower extremities.Methods 486 T2DM patients were divided into PAD group and Non-PAD group according to the value of ABI（the cut point is 0.9）.Two groups were compared and the factors related to ABI were also analyzed.Finally the risk factors of PAD in T2DM were identified.Results Compared with Non-PAD group,the age（62.09±10.53 years vs 56.77±9.83 years,P〈0.01）,diabetes duration（86.90 ± 51.94 month vs 57.91 ± 57.64 month, P 〈 0.01 ） and low density lipoprotein cholesterol （LDLC） （3.07 ± 1.01 mmol/L vs 2.71 ± 0.98 mmol/L, P 〈 0.05） were significantly higher, and ABI （0.77 ±0.15 vs 1.08±0.15, P 〈0.01） was signficantly lower in PAD group. Pearson correlation analysis showed that age and total cholesterol were negatively correlated with ABI. Logistic regression analysis showed that age, diabetes duration, systolic blood pressure （SBP） and LDLC were major risk factors of PAD in T2DM, however, waist hip ratio was a protective factor of PAD. Conclusions ABI is a feasible and reliable index for screening PAD in T2DM patients. Age, diabetes duration, systolic blood pressure and LDLC are major risk factors of low ankle-brachial index in T2DM patients.

关 键 词：内科学 踝肱指数 2型糖尿病 外周动脉疾病 危险因素 

分 类 号：R5[医药卫生—内科学]