硒对急性镉中毒性肾损伤保护作用的研究  

A Study on the Protective Effects of Selenium on Acute Toxic Renal Damage Caused by Cadmium

作　　者：刘爱萍[1,2,3,4,5] 赵金垣[1,2,3,4,5] 刘亚宁[1,2,3,4,5] 赵新华[1,2,3,4,5] 邵涵如[1,2,3,4,5] 龙曼海[1,2,3,4,5] 

机构地区：[1]北京医科大学第三医院职业病研究中心 [2]空军总医院临床检验科发光室 [3]中国科学院高能物理研究所 [4]贵阳医学院毒理学教研室 [5]包头医学院预防医学教研室

出　　处：《中国工业医学杂志》1997年第4期193-197,共5页Chinese Journal of Industrial Medicine

基　　金：国家自然科学基金

摘　　要：研究硒对急性镉中毒性肾损伤的保护作用。给大鼠腹腔注射镉（ＣｄＣｌ２１５μｍｏｌ／ｋｇ）与巯基乙醇（ｍｅｒｃａｐｔｏｅｔｈａｌ，ＭＥ３００μｍｏｌ／ｋｇ）混合液的同时，皮下注射硒（Ｎａ２ＳｅＯ３１５μｍｏｌ／ｋｇ）。结果显示：加硒能明显降低肾皮质镉含量，降低肾线粒体、胞浆氧自由基含量，并可拮抗镉所致大鼠线粒体的脂质过氧化物含量，使ＧＳＨ－Ｐｘ活性在１２小时后显著升高；同时使镉所致肾功能及超微结构损伤得到改善。提示硒可能通过抗氧化作用来防治镉所致肾损伤。Protective effect of selenium on acute toxic renal damage caused by cadmium was studied.Rats were injected simultaneously with a mixture of cadmium chloride 15 μmol/kg and mercaptoethanol 15 μmol/kg intraperitoneally and sodium selenite 15 μmol/kg subcutaneously.Results showed that selenium could reduce the level of cadmium in renal cortex,decrease that of oxygen free radicals in mitochondria and cytoplasm,antagonize the effect of cadmium on the content of lipid peroxide in rat mitochondria,and increase the activity of GSH Px significantly.Also,selenium could improve the damage in renal function and ultra structure caused by cadmium.

关 键 词：硒 镉中毒肾损伤 氧自由基 脂质过氧化 

分 类 号：R135.1[医药卫生—劳动卫生] R692.9[医药卫生—公共卫生与预防医学]