新型络合剂对肾镉促排作用及对微量元素影响的观察  

Effects of Two New Chelating Agents on Renal Excretion of Cadmium and on Trace Elements

作　　者：马东星[1,2,3,4] 赵金垣[1,2,3,4] 王超[1,2,3,4] 陈寿芳 刘年庆[1,2,3,4] 邵涵茹 刘宏[1,2,3,4] 张亨山[1,2,3,4] 

机构地区：[1]北京医科大学第三医院职业病研究中心 [2]中国科学院高能物理所 [3]北京医科大学药学院 [4]武警总医院肾科

出　　处：《中国工业医学杂志》1997年第4期207-210,共4页Chinese Journal of Industrial Medicine

基　　金：国家自然科学基金

摘　　要：为观察新型络合剂Ｇ－Ｃｙｓ－ＤＴＣ、Ｇ－Ｔｈｒ－ＤＴＣ对染毒大鼠肾内蓄积镉的络合促排作用及对肾皮质元素分布的影响，比较促排治疗对肾皮质铁、铜、锌等含量的影响，利用北京正负电子对撞机提供的硬Ｘ射线对肾皮质冰冻切片扫描及原子吸收分光光度法、Ｘ射线荧光测定染毒鼠肾皮质镉及其他元素含量。结果，新型络合剂Ｇ－Ｃｙｓ－ＤＴＣ、Ｇ－Ｔｈｒ－ＤＴＣ能大幅度降低肾内镉负荷。染毒肾皮质中Ｃｄ与Ｓｅ密切相关，而Ｚｎ和Ｓｅ的相关性下降。提示新型络合剂对肾内蓄积镉有较好驱排效果；硒和锌在镉中毒作用机制中可能起一定的保护作用。Effects of two new chelating agents,Dglucosamine N cysteine dithiocarbamate(G Cys DTC) and Dglucosamine threonine dithiocarbamate (G Thr DTC),on the excretion of accumulated cadmium(Cd) in kidney and on the distribution of elements in renal cortex in exposed rats were observed to study comparative influences of the therapy to promote elimination of them on levels of iron,copper,zinc,etc.Contents of Cd and other elements in renal cortex of exposed rats were determined by hard x ray,Produced by Positron and Negatron Collision Machine in Beijing,scanning over frozen section and atomic absorption spectrometry and synchrotron x ray fluorescence.Results showed Cd burden in kidney could be reduced by G Cys DTC and G Thr DTC.Level of Cd correlated closely with that of selenium(Se)in the renal cortex of exposed rats,and correlationship between Zn and Se disappeared.The new chelating agents were much effective in eliminating Cd accumulated in the kidney,and Se and Zn could play a protective role in pathogenesis of cadmium poisoning.

关 键 词：镉 络合剂 二硫代羧酸盐 镉中毒性肾损伤 

分 类 号：R135.1[医药卫生—劳动卫生] R692.9[医药卫生—公共卫生与预防医学]