枸杞在糖尿病大鼠视网膜组织抗氧化反应中的作用  

A research of the effect of lycium barbarum L. to antioxidizing reaction in the retinal tissue of diabetic rats

作　　者：何剑峰 仇宜解[1,2,3] 鲍连云[1,2,3] 张立贵[1,2,3] 

机构地区：[1]柳州市第一人民医院眼科 [2]青岛医学院附属医院眼科 [3]连云港市第一人民医院眼科

出　　处：《中国中医眼科杂志》1997年第3期131-134,共4页China Journal of Chinese Ophthalmology

摘　　要：目的：探讨枸杞在糖尿病大鼠视网膜组织抗氧化反应中的作用。方法：３６只Ｗｉｓｔａｒ大鼠随机分为Ⅰ、Ⅱ、Ⅲ组，其中Ⅱ、Ⅲ组大鼠用链脲佐菌素诱发糖尿病，然后观察枸杞对糖尿病大鼠视网膜组织中剩余抗坏血酸（ｒｅｓｉｄｕａｌａｓｃｏｒｂａｔｅ，ＲＡ）水平，超氧化物歧化酶（ｓｕｐｅｒｏｘｉｄｅｄｉｓｍｕｔａｓｅ，ＳＯＤ）活性及脂质过氧化物（ｌｉｐｉｄｐｅｒｏｘｉｄｅ，ＬＰＯ）含量的短期效应。结果：糖尿病大鼠视网膜组织中ＲＡ水平、ＳＯＤ活性显著下降，ＬＰＯ含量明显增加，但糖尿病枸杞治疗组视网膜组织中ＲＡ水平及ＳＯＤ活性无明显下降，ＬＰＯ含量无明显增加，与糖尿病未治疗组比较均有显著差异（Ｐ＜０．０５）。结论：枸杞具有保护糖尿病大鼠视网膜组织氧化损伤的作用。OBJECTIVE: To study the effect of lycium barbarum L. in antioxidizing reaction in the retinal tissure of diabetic rats. METHODS: 36 wistar rats were divided into I,II,III groups by random, the rats in II, III groups were induced diabetes by streptozotocin, the short-term effects of lycium barbarum L. on the levels of residual ascorbete (RA), the activities of superoxide dismutase (SOD), and the quantities of lipid peroxide (LPO) in retinal tissue of diabetic rats were investigated. RESULTS: In the retinal tissue of diabetic rats, the levels of RA and the activities of SOD were evidently decreased, the quantities of LPO was obviously increased. But, in treated group of lycium barbarum L., RA and SOD were not evidently decreased, LPO was not obviously increased. The difference was sigificance compared with the untreated group of diabetic rats (P<0.05). CONCLUSION: Lycium barbarum L could protect retinal tissue of diabetic rats from oxidizing injury.

关 键 词：糖尿病 实验性 视网膜 枸杞 

分 类 号：R259.871[医药卫生—中西医结合]