前胡丙素对肾性高血压左室肥厚大鼠心功能、左室顺应性及心肌胶原含量的影响  

EFFECTS OF PRAERUPTORIN C ON CARDIAC DYSFUNCTION, MYOCARDIAL COMPLIANCE AND COLLAGEN CONTENT IN RENOVASCULAR HYPERTENSIVE RATS

作　　者：孙兰[1,2] 饶曼人[1,2] 刘培庆[1,2] 

机构地区：[1]南京医科大学心血管药理研究室 [2]中国协和医科大学基础医学院药理室

出　　处：《药学学报》1997年第8期578-582,共5页Acta Pharmaceutica Sinica

摘　　要：观察前胡丙素对肾性高血压左室肥厚（ＬＶＨ）大鼠心功能、左室顺应性及心肌胶原含量的影响。用两肾一夹肾性高血压动物模型，ｉｇ前胡丙素（ＰｒａＣ）９周。结果，与ＬＶＨ组相比，ＰｒａＣ组的ＣＦ／ＨＷＷ及ＣＯ／ＨＷＷ分别增加３１３％和２８９％；ＬＶＳＰ和－ｄｐ／ｄｔｍａｘ负值分别增加１６７％和２７８％；ＬＶＥＤＰ和Ｔ值分别降低３４９％和３６５％；ＰＶ曲线接近正常组水平；左室肌羟脯氨酸降低２３８％。提示ＰｒａＣ可提高ＬＶＨ大鼠心脏收缩及舒张功能。The effects of praeruptorin C (Pra C) on cardiac dysfunction, myocardial compliance, and collagen content in renovascular hypertensive rats have been studied. In rats with left ventricular hypertrophy (LVH), the ratio of cardiac flow (CF)/heart wet weight (HWW) and cardiac output (CO)/HWW decreased by 20 1% and 35 5%; LVSP and -d p /d t max decreased by 19 4% and 42 1%, while LVEDP and T value were increased by 186 4% and 226% The left ventricular diastolic pressure volume (P V) curve was shifted to the left and down ward compared with that of sham operated rats. The hydroxyproline content was 5 93±0 82 mg·g -1 dry weight in the left ventricular myocardial tissue of rats with LVH which was higher than that of sham operated rats(eg 4 01±0 47 mg·g -1 ). The content did not change in the right ventricular myocardium. After treated with Pra C for nine weeks, the CF/HWW and CO/HWW increased by 31 3% and 25 1%, the LVSP and -d p /d t max increased by 16 7% and 27 8%. The LVEDP and T value was reduced by 34 9% and 36 5%, respectively, compared with those of LVH. The P V curves of these rats were shifted to the right and in the up ward direction. The hydroxyproline content was 4 52±0 3 mg·g -1 dry weight in the left ventricular tissue. These results indicate that Pra C improved the cardiac contractility and relaxation by increasing the coronary flow and cardic output, and decreasing the collagen content in the ventricular myocardium.

关 键 词：前胡丙素 心功能 心肌顺应性 肾性高血压 

分 类 号：R544.140.5[医药卫生—心血管疾病] R972[医药卫生—内科学]