酪氨酸单用及合并RU486对小鼠生殖功能的影响及作用机理  

EFFECTS OF TYROSINE ALONE AND TYROSINE IN COMBINATION WITH RU486 ON EARLY PREGNANCY IN MICE AND THE MECHANISM OF ACTION

作　　者：段红[1] 王乃功[1] 

机构地区：[1]中国医学科学院中国协和医科大学药物研究所

出　　处：《药学学报》1997年第8期583-585,共3页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金

摘　　要：用小鼠抗早孕实验及体外大鼠黄体细胞培养的方法，研究酪氨酸单用及酪氨酸与已知抗生育药ＲＵ４８６合并用药对小鼠早期妊娠的影响及作用机制。结果表明，酪氨酸与ＲＵ４８６合用有协同抗早孕作用。进一步的机理研究发现，酪氨酸１７０ｍｇ·ｋｇ－１·５ｄ可使早孕小鼠血清孕酮水平显著降低；酪氨酸５０μｇ·ｍｌ－１与（＋）ＰＧ０５合用；对抑制大鼠黄体细胞孕酮的基础分泌有协同作用，并能显著抑制ｈＣＧ诱导的大鼠黄体细胞孕酮的分泌。结果提示：降低孕酮分泌可能是酪氨酸抗生育作用的途径之一。Treatment with tyrosine at the dosage of 85 mg·kg -1 on day 6～8 of gestation did not have significant effect to terminate early pregnancy in mice. Tyrosine combined with RU486 was shown to have a synergistic effect to terminate early pregnancy. Tyrosine 170 mg·kg -1 on day 6～10 of gestation significantly decreased the concentration of serum progesterone in early pregnant mice. Further study with luteal cells in rats showed that tyrosine 50 μg·ml -1 inhibited hCG induced progesterone production when used alone, and inhibited basal production when used together with (+)PG05. These results suggest that the inhibiting effect of tyrosine on steroidogenesis may contribute to the termination of early pregnancy.

关 键 词：酪氨酸 抗早孕 RU486 药理学 

分 类 号：R979.2[医药卫生—药品]