纳曲酮对移植排异反应的抑制作用  

The suppressive effect of naltrexone on transplantation rejection

作　　者：汪静雪[1,2] 李怡凡[1,2] 邵黎[1,2] 丁桂凤 范少光[1,2] 

机构地区：[1]北京医科大学生理学系 [2]河北省廊坊师范学院生理教研室

出　　处：《中华微生物学和免疫学杂志》1997年第2期107-110,共4页Chinese Journal of Microbiology and Immunology

基　　金：国家攀登计划;国家自然科学基金;卫生部基金

摘　　要：以小鼠心肌组织异位移植和混合淋巴细胞反应为整体和离体模型，观察了阿片受体阻断剂纳曲酮对移植排异反应的影响。结果显示：给动物从术前开始腹腔注射纳曲酮共１０天（每日二次，每次５ｍｇ／ｋｇ）可明显延长移植心肌组织的存活时间；加入纳曲酮（１０－４～１０－８ｍｏｌ／Ｌ）对混合淋巴细胞反应有抑制作用并呈量效关系。同时还观察到，给正常小鼠腹腔注射纳曲酮３天以上，可引起动物脾细胞由ＣｏｎＡ诱导的淋巴细胞转化反应受抑制。以上结果说明纳曲酮可抑制移植排异反应，此作用有可能是通过阻断内源性阿片肽所致。In vivo experiment,allografting of cardiac tissue into mouse ear,and in vitro experiment,mixed lymphocyte reaction was used to investigate the effect of naltrexone,an antagonist of opioid receptor,on transplantation rejection.The results showed that naltrexone,which was injected intraperitoneally(5mg/kg,twice a day)for 10 days just before operation,prolonged significantly survival of the grafts.It was also found that naltrexone(10 -4 ￣10 -8 mol/L) significantly inhibited one way mixed lymphocyte reaction in a dose dependent manner.In normal mice which were injected with naltrexone intraperitoneally for more than 3 days,the Con A induced lymphocyte proliferation of splenocyte decreased.All the results mentioned above indicated that naltrexone was effective on suppressing transplantation rejection and the suppressive effect was probably induced by blocking the action of the endogenous opioid peptides released during the transplantation.

关 键 词：移植物 排斥反应 纳曲酮 免疫抑制 

分 类 号：R392.4[医药卫生—免疫学] R971.93[医药卫生—基础医学]