片姜黄对去卵巢肥胖大鼠的影响  

Effects of Rhizoma Wenyujin Concisum on ovariectomized obese rats

作　　者：李旭炯[1] 岳嘉[1] 常燕琴[1] 蔺美玲[1] 张小郁[1] 丁永辉 郑天珍[1] 

机构地区：[1]兰州大学基础医学院生理与心理学研究所 [2]甘肃省食品药品监督管理局,甘肃兰州730030

出　　处：《中国现代医学杂志》2008年第4期405-407,412,共4页China Journal of Modern Medicine

基　　金：国家自然科学基金资助项目(No:30572428)

摘　　要：目的观察片姜黄水煎剂对去卵巢大鼠肥胖影响,初步探讨其作用机制。方法切除大鼠双侧卵巢,制备去卵巢肥胖的动物模型,观察片姜黄水煎剂对去卵巢肥胖大鼠体重、摄食的影响及血清雌二醇(E2)、血脂水平、丙二醛(MDA)和肿瘤坏死因子-α(TNF-α)的变化。结果去卵巢大鼠体重及Lee's指数显著增加,血清三酰甘油(TG)、MDA和TNF-α水平明显升高,但E2水平明显降低。口服片姜黄显著降低了去卵巢引起的大鼠体重、Lee's指数的增加。并使血清TG、MDA、TNF-α水平明显降低。结论口服片姜黄水煎剂可抑制去卵巢大鼠的肥胖,提高机体的抗氧化力,改善脂代谢。[Objective] To observe the effect of the water decoction of Rhizoma Wenyujin Concisum on obesity in ovariectomized rat and primarily research its mechanism. [Methods] After ablating bilateral ovaries,SD rats drank water extracts of Rhizoma Wenyujin Concisum and its effects on body weight were observed. On 55th day, blood was collected to assay estrogen（E）, malondialdehyde 0MDA）, triglycefide （TG） and tumor necrosis factor-alpha （TNF-α） levels. [Results] Rats in OVX group displayed higher weight, Lee＇s index, TG and MDA,lower serum levels of estrogen. After drinking water extracts of Rhizoma Wenyujin Concisum, compared with OVX group,rats in OVX ＋ RWC group had lower weight, levels of MDA, TG and TNF-α. [Conclusion] Rhizoma Wenyujin Concisum could promote weight loss in OVX rats. It can elevate anti-oxidative capacity and improve lipid metabolism,

关 键 词：片姜黄 肥胖 雌激素 肿瘤坏死因子-Α 

分 类 号：R711.75[医药卫生—妇产科学] R-332[医药卫生—临床医学]