手性化合物(S)-3-羟基四氢呋喃的合成  

Synthesis of chiral (S)-3-hydroxytetrahydrofuran

作　　者：李勇智[1] 宁斌科[1] 丁秀丽[1] 

机构地区：[1]西安近代化学研究所,陕西西安710065

出　　处：《应用化工》2008年第2期191-194,共4页Applied Chemical Industry

摘　　要：以(S)-4-氯-3-羟基丁酸乙酯为原料,经过还原和环化两步反应得到目标产物(S)-3-羟基四氢呋喃;还原反应最佳温度为40℃,时间为4 h;环化反应最佳温度为80℃,时间为20 h;本论文所合成的目标化合物及中间体的化学结构均经过元素分析、红外光谱、核磁共振以及质谱分析鉴定。反应总收率为75.2%,纯度达到99.3%,光学纯度达到96.3%。Ethyl 4-chloro-（ S）-3-hydroxybutyrate was used as the starting materials to give （S）-3- hydroxytetrahydrofuran which was synthesized by the process of deoxidization and cyclization. The optimum temperature and time of the deoxidization were 40℃ and 4 h. The optimum temperature and time of the cyclization were 80 ℃ and 20 h. The chemical structures of the target compound and the intermediate were identified by element analysis, IR, NMR and MS spectra. The total yield and the purity of the product were 75.2% and 99.3% ,the optical purity was 96.3%.

关 键 词：(S)-3-羟基四氢呋喃 合成 手性 

分 类 号：TQ463.53[化学工程—制药化工]