冠心病患者低高密度脂蛋白血症与冠脉病变分析  

Study of hypo-high-density-lipoproteinemia and coronary artery lesions in patients with coronary heart disease

作　　者：张学频[1] 史震涛[1] 范常峰[1] 

机构地区：[1]北京大学首钢医院,北京100041

出　　处：《现代中西医结合杂志》2008年第9期1299-1300,共2页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的探讨血浆高密度脂蛋白(HDL)水平与冠脉病变的关系。方法选择经冠状动脉造影确诊为冠心病患者100例,其中50例伴有低HDL,50例血脂正常,对2组患者临床资料进行比较。结果低HDL组冠状动脉病变累及左主干6例(12%),对照组1例(2%)(P<0.05)。病变狭窄95%以上者低HDL组34例(68%),对照组19例(38%)(P<0.05);低HDL组冠状动脉病变累及左前降支和左回旋支分别为36例(72%)和31例(62%),明显高于对照组的26例(52%)和22例(44%)(P均<0.05);TiMi分级为0级者低HDL组10例(20%),对照组4例(8%)(P<0.05)。结论血浆HDL与冠脉病变程度具有负相关关系。Objective It is to approach the relationship between the level of high-density-lipoproteinemia （HDL） and coronary artery lesion in patients with coronary heart disease （CHD）. Methods 100 patients with CI-ID were diagnosed by coronary angiography, which 50 cases with hypo-IDL and 50 cases with normal lipidemia. The clinical data in both two groups were compared. Results In hypo-HDL groups the rate of which coronary artery lesions had been involved in LM was 12 %, while that in the control group was 2%. In hypo-HDL group the number of the cases with more than 95 % stenosis was 34, while that in the control group was 19. In hypo-HDL group the rate of which coronary artery lesions had been involved in LAD and LCX was respectively higher than the control group with the former at 72 % and 62 % and the latter at 52 % and 44 %. In hypo-HDL group the TIMI 0 flow was 20 % while that in the control group was 8 %. There was significant difference on these indexes between the two group （ P 〈 0,05）. Conclusion Plasma HDL correlated negatively with coronary artery lesions.

关 键 词：冠状动脉造影 高密度脂蛋白 血脂 

分 类 号：R541.4[医药卫生—心血管疾病]