L-4-溴-2-氨基丁酸的“两锅法”合成  

Synthesis of L-2-amino-4-bromobutanoic acid

作　　者：何伟彪[1] 张逸伟[1] 陈海权[1] 

机构地区：[1]华南理工大学化学科学学院,广东广州510641

出　　处：《化学试剂》2008年第2期117-119,共3页Chemical Reagents

基　　金：广东省重点科技攻关项目(2003C104043)

摘　　要：L-蛋氨酸经过甲基化、水解和脱水关环3步"一锅法"反应得到中间体L-α-氨基-γ-丁内酯盐酸盐,收率69.0%。再与33.7%的溴化氢乙酸溶液在耐压瓶中于70℃反应9h,得到目标化合物,收率86.2%。用核磁共振氢谱和比旋光度分析对中间产物和目标产物进行了表征,还探讨了目标化合物在室温下的不稳定性及其转化机理。The intermediate L-a-amino- 7-butyrolactone hydrochloride was synthesized starting from L-methionine in ＂onepot＂ process via 3 steps including methylation, hydrolysis and cycllzation, With a yield of 69.0 %. Then this compound reacted upon a solution of hydrobromie acid in acetic acid （33.7%） to give the target compound at a yield of 86.2%. ^1HNMR spectrometry and specific rotation analysis were used to characterize the intermediate and the title compound. The lability of the target compound and its transformation mechanism at room temperature were also studied.

关 键 词：L-蛋氨酸 L-4-溴-2-氨基丁酸 合成 不稳定性 

分 类 号：O629.71[理学—有机化学]