5-(3,4,5-三-十二烷氧基苯乙烯基)-2,4,6-(1H,3H)-嘧啶三酮的合成  

Synthesis of 5-[3,4,5-tris(n-dodecan-1-yloxy)benzylidene]-2,4,6-(1H,3H)-pyrimidine-trione

作　　者：黄燎[1] 杨新国[1] 赵秋丽[1] 卓立[2] 

机构地区：[1]湖南大学材料科学与工程学院,湖南长沙410082 [2]江苏北方氯碱集团有限公司,江苏徐州221007

出　　处：《化学试剂》2008年第2期139-140,共2页Chemical Reagents

基　　金：国家自然科学基金资助项目(50573019)

摘　　要：以没食子酸甲酯为原料,与1-溴代十二烷醚化生成3,4,5-三-(十二烷氧基)苯甲酸甲酯,然后采用原位生成的硼氢化锂还原成3,4,5-三-(十二烷氧基)苯甲醇,再用氯铬酸吡啶盐(PCC)氧化成3,4,5-三-(十二烷氧基)苯甲醛,最后与巴比妥酸进行Knoevenagel缩合反应得到了标题化合物。该合成路线简单,原料价廉,操作简便,产率高,易于常量合成。This paper provided a more simple, convenient and ef- ficient route for synthesis of 5- [ 3,4,5-tris （ n-dodecan- 1-yloxy） benzylidene ] -2,4,6- （ 1 H, 3 H ）-pyrimidine- trione. Firstly, 3,4,5- tris（n-dodecan-l-yloxy） benzyl alcohol was synthesized by the alkylation of methyl-3,4,5-trihydroxylbenzoate with 1-bromodo- decane, followed by the reduction of 3, 4,5-tris（ n-dodecan-1yloxy） benzoate with lithium borohydride; then 3,4,5- tris（ n- dodecan-l-yloxy）benzyl aldehyde was obtained through oxidation of 3,4, 5-tris （n-dodecan-l-yloxy）benzyl alcohol with pyridinium chlorochromate ;and finally the compound was synthesized by the Knoevenagel condensation reaction with barbituric acid.

关 键 词：没食子酸甲酯 巴比妥酸 硼氢化锂 合成 

分 类 号：O626.41[理学—有机化学]