桃叶珊瑚苷对糖尿病大鼠线粒体的抗氧化作用  

Antioxygen effects of Aucubio on mitochondria in diabetic rats

作　　者：金雷[1] 薛宏宇[1] 金礼吉[1] 徐永平[1] 

机构地区：[1]大连理工大学,辽宁大连116024

出　　处：《山东医药》2008年第4期16-18,共3页Shandong Medical Journal

基　　金：国家杰出青年科学基金资助项目(30125034)

摘　　要：目的研究桃叶珊瑚苷对链脲佐菌素(STZ)诱导的糖尿病大鼠血糖和线粒体抗氧化能力的影响。方法通过STZ腹腔注射建立糖尿病大鼠模型,将其随机分为糖尿病组、STZ低剂量组和STZ高剂量组,并与空白对照组比较。观察桃叶珊瑚苷治疗前后糖尿病大鼠的形态、体质量、血糖、线粒体内脂质过氧化和抗氧化体系的变化。结果与空白对照组比较,糖尿病大鼠血糖、MDA显著升高,CAT、GSH-Px、SOD活力显著下降;桃叶珊瑚苷治疗后血糖、MDA显著降低,CAT、GSH-Px、SOD活力显著升高。结论桃叶珊瑚苷能显著降低糖尿病大鼠的血糖值,改善线粒体的抗氧化水平,是一种潜在的防治糖尿病药物。Objective To investigate the effects of Aucubin on blood glucose levels and mitochondria antioxidant capacity in streptozotocin-induced diabetic rats. Methods Diabetic rats were induced by intraperitoneal injection of STZ. Rats were randomly allocated into diabetic group, low dose group, high dose group and normal control group. During and after the treatment, the general state, body weight, blood gloucose, lipid per-oxidative level and antioxidative enzymes activities in mitochondria were observed. Results The level of blood glucose and MDA in the diabetic group significantly increased, and the activities of CAT, GSH-Px and SOD vigor reduced significantly. After the administration of Aucubin, the level of blood glucose and MDA in the diabetic group reduced significantly, as well as the activities of CAT, GSH-Px and SOD increased significantly. Conclusion This study showed that Aucubin administration could reduce the level of blood glucose, improve mitochondria antioxidant capacity in diabetic rats. Thus, Aucubin may be implicated as a preventive medicine against diabetes mellitus.

关 键 词：桃叶珊瑚苷 糖尿病 血糖 线粒体 抗氧化 

分 类 号：R587[医药卫生—内分泌]