相转移催化与微波技术用于苯丙氨酸合成  

Application of Phase Transfer Catalysis and Microwave Irradiation in Chemical Synthesis of Phenylalanine

作　　者：赵晨曦[1,2] 李志良[1,2] 肖敏 

机构地区：[1]湖南省微生物研究所 [2]湖南大学化学化工系

出　　处：《氨基酸和生物资源》1997年第2期15-17,共3页Amino Acids & Biotic Resources

基　　金：国家自然科学基金

摘　　要：采用微波辐射技术结合固液相转移催化进行有机合成，明显地加速了有机反应速率甚至提高了合成产率。以苯甲基叉亚胺的苄基化反应为例，仅用１ｍｉｎ时间便能完成反应。然后经酸性水解得苯丙氨酸消旋体。整个合成路线全程总产率达６２．５％，操作简便。A novel synthetic method for chemically preparing phenylalanine was reported. Microwave irradiation technique and phase transfer catalysis(MIT/PTC) were used in this method. The reaction rate was greatly increased and even the product yield was fairly risen. By using phase transfer catalysis, the benzoldehyde imine was realized under microwavei rradiation within only one minute. After acidic hydrolysis, phenylalanine was obtained with total yield of 62.5%. The procedure was easily realizable.

关 键 词：苯丙氨酸 相转移催化 微波辐射技术 合成 

分 类 号：Q517.03[生物学—生物化学]