钙调蛋白拮抗剂——小檗胺及其衍生物对正常牛胚肾细胞毒性的影响  

CALMODULIN ANTAGONIST-EFFECTS OF BERBAMINE AND ITS DERIVATIVES ON THE CYTOTOXITY OF NORMAL CELLS (MDBK)

作　　者：张金红[1] 耿朝晖[1] 段江燕[1] 陈家童[1] 贺宏 黄建英[2] 

机构地区：[1]南开大学分子生物学研究所,天津300071 [2]天津市肿瘤研究所

出　　处：《细胞生物学杂志》1997年第2期76-79,共4页Chinese Journal of Cell Biology

基　　金：天津市自然科学基金

摘　　要：本文研究了4种小檗胺类化合物对正常牛胚肾细胞(MDBK)生长增殖和细胞内钙调蛋白(CaM)水平的影响。结果发现,小檗胺及其衍生物对MDBK细胞的增殖都有抑制作用,但小檗胺的影响大于衍生物,而衍生物中,结构略复杂的EBB对MDBK细胞影响最小。实验结果还发现四种化合物均能不同程度地降低MDBK细胞内CaM的水平。We have observed the activation of the structure of four berbamine compounds on the growth and proliferation of MDBK cells in vitro and the change of CaM content before and after the treatment with berbamine compounds.The results suggested that berbamine and its derivatives all have inhibitory activated on the proliferation of MDBK cells. But the cytotoxity of berbamine on the growth of MDBK celis is more greatly than its derivatives. The study demonstrated that modified berbamine dervative- EBB is a potent drug of anticancer for future investigation and developed.The results also appeared that CaM content of the celis has decrease during the activation of these compounds on the MDBK cells.

关 键 词：小檗胺 小檗胺衍生物 免疫制剂 肾细胞 细胞毒性 

分 类 号：R979.5[医药卫生—药品]