健康人群谷胱甘肽硫转移酶M1基因型分布  

Study on genetic polymorphism of glutathione S-transferase M1 in healthy Han and Yao population

作　　者：王国彬[1] 陈海珍[1] 杨杏芬[1] 陈瑞梅[2] 禤汝流 杨颍[1] 黄俊明[1] 李文立[1] 

机构地区：[1]广东省疾病预防控制中心,广州510300 [2]广东省清远市疾病预防控制中心

出　　处：《中国公共卫生》2008年第3期323-324,共2页Chinese Journal of Public Health

基　　金：广东省自然科学基金团队项目(015042)

摘　　要：目的探讨广东地区瑶族和汉族健康人群谷胱甘肽硫转移酶M1(GSTM1)基因多态性的分布。方法采用双重PCR方法检测237例瑶族和229例汉族人群GSTM1基因型。结果瑶族和汉族人群GSTM1缺失基因型频率分别为68.35%(162/237)及64.19%(147/229),2者之间差异无统计学意义(P>0.05);同民族不同性别之间差异亦无统计学意义(P>0.05)。结论广东地区瑶族和汉族健康人群GSTM1基因呈多态性分布。Objective To investigate the distribution of glutathione-S-tran sferase M1（GSTM1）gene polymorphism in health Yao and Han nationalities of Guangdong povince.Methods The genotypes of GS.TM1 in 237 Yao and 229 Han people were detected by duplicate PCR technique.Results The frequency of GSTM1 null genotype in Yao nationality was 68.35%（162/237）,where as that in Han nationality was 64.19%（147/229）.No significant difference between the frequencies of these two groups was observed（P〉0.05）.There were also no statistical differences between that of males and females within the same nationality（P〉0.05）.Conclusion Distributions of GSTM1 genes are polymorphic in Han and Yao population in Guangdong,China.

关 键 词：谷胱甘肽硫转移酶 多态性 少数民族 

分 类 号：R181.3[医药卫生—流行病学]