鳗鱼降钙素对绝经后骨质疏松症的疗效观察  

Effects of elcitonin on postmenopausal osteoporosis

作　　者：宣淼[1] 张秀珍[1] 

机构地区：[1]同济大学附属同济医院内分泌科,上海200065

出　　处：《同济大学学报（医学版）》2008年第1期56-58,共3页Journal of Tongji University(Medical Science)

基　　金：国家自然科学基金资助项目(30070357)

摘　　要：目的探讨鳗鱼降钙素治疗绝经后骨质疏松症的疗效。方法将70例绝经后骨质疏松症患者随机分为两组,治疗组40例,应用鳗鱼降钙素治疗,20 IU肌注每周一次,疗程6个月;对照组30例。两组均口服钙尔奇D（含元素钙600 mg,维生素D125 IU）每天一片,疗程6个月。两组治疗前后均测定2-4腰椎、骨股颈及wards三角骨密度（bone mineral density,BMD）,记录患者临床症状。结果治疗组2个月后骨痛改善率高于对照组（P〈0.01）,治疗组患者腰2、腰3、腰椎均值BMD较前明显升高（P〈0.05）。对照组BMD治疗前后无明显变化（P〉0.05）。结论鳗鱼降钙素与钙剂联合应用对治疗绝经后骨质疏松症有减轻疼痛,改善症状,同时增加骨密度作用。Objective To evaluate the effect of elcatonin on postmenopausal ostcoporosis patients, Methods Seventy cases of postmenopausal osteoporosis were randomly divided into elcatonin treatment group （ n = 40） and the control group （ n = 30）. The cases in treatment group were intramuscularly injected elcatonin 20 IU once a week for 6 months continuously. Patients in both two groups were given calcium carbonate vitamin D per day for 6 months. Bone mineral density （BMD） of lumbar spine, neck of femur and region of wards were measured and clinical symptoms were recorded before and after treatments. Results A significant difference in bone pain relieving was found between treatment group and control group after two months treatment （P〈 0.01 ）. And BMD of lumbar spine （L2, L3, average of） in treatment group increased significantly after treatments （ P 〈 0.05）. However, BMD had no obvious changes in control group （P 〉 0.05）. Conclusion The bone pain can be relieved and BMD will be improved after administration of elcatonin combined with calcium supplement.

关 键 词：骨质疏松 降钙素 绝经 骨密度 

分 类 号：R681[医药卫生—骨科学]