槲芪散对肝癌前病变大鼠肝脏线粒体结构的影响  

Effects of Huqisan(槲芪散) on chondriosome structure in hepatic precancerosis of rats

作　　者：丰平[1] 刘树红[1] 李霞[1] 李向利[1] 王学江[1] 史争鸣[2] 

机构地区：[1]首都医科大学基础医学院,北京100069 [2]北京积水潭医院,北京100035

出　　处：《中药药理与临床》2008年第1期56-57,共2页Pharmacology and Clinics of Chinese Materia Medica

基　　金：北京市中医药科技发展项目基金(JJ2003-7,JJ2005-10);北京市教育委员会科技发展计划项目(KM200610025003)

摘　　要：目的:探讨槲芪散对肝癌前病变大鼠肝脏线粒体结构的影响。方法:用二乙基亚硝胺建立Solt-Earber二步肝癌前短期动物模型,以槲芪散对肝癌前病变大鼠进行治疗。通过电镜观察大鼠肝脏的线粒体结构变化。结果:二乙基亚硝胺所引起的肝癌前病变大鼠可出现肝细胞线粒体肿胀、空泡和嵴消失,槲芪散可减轻大鼠肝癌前病变模型肝细胞内线粒体肿胀。结论:槲芪散可减轻由二乙基亚硝胺所引起的肝癌前病变大鼠肝脏线粒体结构的损伤。Objective：To investigate the effect of Huqisan（HQS） on the chondriosome structure in hepatic precancerosis of rats. Methods：A Solt- Farber two-step test model of prehepatocarcinoma was established by diethylnitrosamine （DEN） and 2-acetylaminofluorene （2-AAF） in rats at dose of 200mg/kg body weight for one time. The normal controls were injected with physiologic saline. Hepatic precancerosis rats were simultaneously treated by different dose of HQS as the hepatic precancerosis. The hepaticultra structure of all rats was observed by electronmi- croscope. Results：The change of hepaticultra structure could be observed in precancerosis rats. The ultra structure changes in clued swollen mitochondria, enlargement of endoplasmic reticulum, condensation and lipid droplet in cytoplasm. HQS could reduce formation of lipid droplet, oliferation of endoplasmic reticulum, swelling of chondriosome and proliferation of interstitial collagen in hepatic cells of precancerosis rats. Condusion：HQS could relieve the damage of hepatic chondriosome structure in precancerosis rats.

关 键 词：肝癌前病变 槲芪散 线粒体结构 

分 类 号：R285[医药卫生—中药学]