吸烟人群巨噬细胞移动抑制因子-173位点基因多态性与冠心病的关系  

Association of MIF - 173 gene polymorphism with coronary heart disease in Chinese cigarette smoking population

作　　者：林斌[1] 傅国胜[2] 李长岭[2] 黄翯[2] 茅焕豪[2] 张佩[2] 周斌全[2] 

机构地区：[1]温州市第二人民医院心内科 [2]浙江大学医学院附属邵逸夫医院心内科,浙江大学邵逸夫临床医学研究所,浙江杭州310016

出　　处：《全科医学临床与教育》2008年第1期31-34,共4页Clinical Education of General Practice

摘　　要：目的研究中国浙江汉族吸烟人群中巨噬细胞移动抑制因子(MIF)基因-173位点单核苷酸多态性与冠心病的相关性。方法采用聚合酶链反应和限制性内切酶片段长度多态性方法,对冠心病组(至少1支冠脉直径狭窄≥50.00%)67例、对照组72例检测巨噬细胞移动抑制因子173位点基因多态性。结果MIF基因-173位点检测到3种基因型,其基因型分布符合Hardy-Weinberg平衡定律。冠心病患者MIF-173基因型分布与对照组比较差异有统计学意义(χ2=6.35,P<0.05)。冠心病患者MIF-173C等位基因频率与对照组比较差异有统计学意义(χ2=7.14,P<0.01)。结论MIF基因-173G/C位点多态性与吸烟人群的冠心病发病有关,C等位基因可能是浙江汉族吸烟人群冠心病的易感性标志。Objective To investigate the relationship between the-173 single nucleotide polymorphism （SNP） of macrophage migration inhibitory factor （MIF） gene and angiographically documented coronary heart disease （CHD）in Chinese cigarette smoking population. Methods Migration inhibitory factor-173 genotypes were investigated with PCR in 67 patients complicated with CHD and 72 controls. Results Three kinds of genotypes at the MIF-173 locus were detected , and no deviation was observed from Hardy-Weinherg equilibrium. There was significant difference in MIF-173 genotype distribution between patients and controls （X^2=6.35, P〈0.05）. Significant differences in genotype frequencies of MIF-173 C allele were found between CHD and those without CHD （X^2=7.14, P〈0.01）. Conclusion These results suggest that MIF-173G/C polymorphism is associated with CHD in Chinese cigarette smoking population, the MIF-173C allele might be a risk factor for CHD in Chinese Han smokers in Zhejiang province.

关 键 词：冠状动脉粥样硬化性心脏病 巨噬细胞移动抑制因子 单核苷酸多态性 吸烟 

分 类 号：R541.4[医药卫生—心血管疾病]