1995年和2005年广州地区心血管病患者血脂水平调查  

Plasma lipid level in patients with cardiovascular diseases:a survey for changes over the 10-year period between 1995 and 2005 in Guangzhou

作　　者：李鹏[1] 郭志刚[1] 李勇[1] 许顶立[1] 

机构地区：[1]南方医科大学南方医院心内科,广东广州510515

出　　处：《南方医科大学学报》2008年第2期184-187,192,共5页Journal of Southern Medical University

基　　金：国家自然科学基金(30471929);广东省自然科学基金(06024407)~~

摘　　要：目的研究1995年与2005年广州心血管病患者的血脂水平,以及10年间血脂变化情况。方法采取整群抽样的方法将南方医院1995年和2005年心内科住院病人作为研究样本(1768人),并分为单纯高血压患者、单纯冠心病或其等危症患者、冠心病合并冠心病等危症患者、高血压合并冠心病或者合并冠心病等危症患者、高血压合并冠心病合并冠心病等危症患者、其他心血管病患者6组,然后由统计教研室对其血脂水平及分布特点进行统计学分析。结果(1)1995年与2005年调查人群血脂水平均有显著性差异,TG、TC、HDL-C水平均为2005年高于1995年,而LDL水平2005年低于1995年;(2)1995年调查人群的血脂水平在性别上无显著性差异,而2005年调查人群的血脂TG、HDL-C水平在性别上均有显著性差异,表现为TG男性高于女性,HDL-C女性高于男性,而TC、LDL-C无性别差异;(3)1995年心血管病不同患病人群组血脂TG、TC、LDL-C水平均有显著性差异,且均为单纯高血压患者组最高,而2005年不同患病人群组血脂4项水平均有显著性差异,表现为高血压合并冠心病或者合并冠心病等危症患者组、高血压合并冠心病合并冠心病等危症患者组TG水平最高,高血压合并冠心病合并冠心病等危症患者组TC水平最高,冠心病合并冠心病等危症患者组HDL-C水平最低,单纯高血压患者组LDL-C平均最高。结论广州心血管病患者血脂水平10年来发生了显著性变化,并且存在性别差异。单纯高血压患者组血脂水平普遍高于其他患病组人群。Objective To study the plasma lipid level in patients with cardiovascular disease in Guangzhou and investigate its changes over the 10 years from 1995 to 2005. Methods According to the cluster sampling method, 1768 patients were selected for the study from the total patients admitted in the Department of Cardiology of Nanfang Hospital between 1995 and 2005. These patients were divided into 6 groups, namely uncomplicated hypertension group, coronary artery disease （CAD） or CAD risk equivalent group, CAD complicated by CAD risk equivalent group, hypertension complicated by CAD or CAD risk equivalent group, hypertension complicated by CAD and CAD risk equivalent group, and other cardiovascular disease group. The data of the plasma lipid levels in these patients were analyzed statistically. Results Significant changes occurred over the decade in the plasma lipid levels of these surveyed patients, and the TG, TC and HDL-C levels were significantly higher, but LDL-C levels significantly lower in patients surveyed in 2005 than in those surveyed in 1995. In 1995, the patients did not show gender-related difference in the plasma lipids, but till 2005, TG and HDL-C levels of the patients began to exhibit significant difference between genders. In 1995, patients with uncomplicated hypertension had the highest levels ofTG, TC, and HDL-C among the patients of different cardiovascular conditions, but in 2005 this picture underwent obvious changes, and TG, TC, HDL-C, and LDL-C levels differed significantly between patients with various conditions. Conclusions Plasma lipid levels of patients with cardiovascular diseases show significant changes over the 10 years with gender-related differences. In general, patients with uncomplicated hypertension have higher plasma lipid levels than those with other cardiovascular conditions.

关 键 词：血脂 冠心病 心血管疾病 血脂异常 

分 类 号：R54[医药卫生—心血管疾病]