帕罗西汀片在健康人体的药代动力学  

Pharmacokinetics of paroxetine tablet in healthy Chinese volunteers

作　　者：朱军[1] 刘伟忠[2] 杨鸿[1] 刘文宪[2] 王华成[2] 林育华[2] 刘义 

机构地区：[1]中山大学附属第二医院药学部,广东广州510120 [2]广州市精神病医院／国家药品临床研究基地,广东广州510370 [3]卫材(中国)药业有限公司,广东广州510080

出　　处：《南方医科大学学报》2008年第2期260-262,共3页Journal of Southern Medical University

摘　　要：目的研究帕罗西汀片在健康人体内的药代动力学。方法20名健康志愿者单剂量口服40mg帕罗西汀片后,用高效液相色谱法测定血浆中帕罗西汀浓度,并用3P97软件统计处理。结果帕罗西汀片药-时曲线经拟合呈二室模型,其Cmax、Tmax、t1/2、AUC0-120、AUC0-inf分别为(64.74±18.43)ng/ml、(5.64±1.84)h、(20.03±5.33)h、(976.47±309.49)ng·h/ml和(1086.75±376.54)ng·h/ml。结论帕罗西汀片在人体内的药代动力学呈二房室开放模型。Objective To study the pharmacokinetics of paroxetine tablet in Chinese healthy volunteers. Methods Twenty healthy subjects received a single oral dose of 40 mg paroxetine tablet. The plasma concentrations of paroxetine were determined using high-performance liquid chromatography （HPLC） and the measurements were analyzed with 3P97 program. Results The plasma concentration curve of paroxetine following a single oral dose administration conformed to the two-compartment open model. The main pharmacokinetics parameters of paroxetine were： Cmax 64.74±18.43 ng/ml, Tmax 5.64±1.84h, t1/2 20.03±5.33 h, AUC0-120 976.47±309.49 ng·h/ml, and AUC0-inf 1086.75±376.54ng·h/ml. Conclusion The pharmacokinetics of paroxetine in human body conforms to the two-compartment open model.

关 键 词：帕罗西汀 药代动力学 高效液相色谱法 

分 类 号：R96[医药卫生—药理学]