西安地区无前列腺疾患男性fPSA百分比相关检测结果分析  

Analysis of the results of percent free prostate specific antigen detection among the men without prostate diseases in Xi'an

作　　者：张鹏[1] 王子明[1] 种铁[1] 赵丽华[2] 

机构地区：[1]西安交通大学医学院第二附属医院泌尿外科,陕西西安710004 [2]西安交通大学医学院第二附属医院检验科,陕西西安710004

出　　处：《南方医科大学学报》2008年第2期269-271,共3页Journal of Southern Medical University

摘　　要：目的测定西安地区无前列腺疾患男性游离前列腺特异性抗原(fPSA)百分比,研究年龄对fPSA百分比的影响及fPSA百分比与前列腺癌病理分级及临床分期的关系,分析其与国外资料的差异,探讨适合于中国人的fPSA百分比参考值范围。方法选择829例男性,其中无前列腺疾患男性775例,按年龄不同分为5组,测定血清PSA、fPSA并计算fPSA百分比,研究年龄与PSA、fPSA、fPSA百分比相关性。另选54例经病理证实的前列腺癌患者,研究fPSA百分比与前列腺癌病理分级及临床分期的关系,结合无前列腺疾患男性的fPSA百分比,确定适合于中国人的fPSA百分比参考值范围。结果PSA、fPSA与年龄相关,fPSA百分比与年龄无关。fPSA百分比与前列腺癌病理分级及临床分期相关。西安地区无前列腺疾患男性fPSA百分比值显著低于国外资料报道。适合于中国人的fPSA百分比参考值范围为≥15%。结论fPSA百分比不受年龄因素影响,临床价值优于PSA。随着前列腺癌病人fPSA百分比降低,其病理分化程度降低,临床分期增加,恶性程度增高。国外资料报道的fPSA百分比参考值范围不适用于中国人,中国人应建立自己的fPSA百分比参考值范围。适合于中国人的fPSA百分比参考值范围为≥15%。Objective To measure the percentage of free prostate specific antigen （tPSA） among the men without prostate diseases in Xi＇an, and understand the age-related changes in percent tPSA and its association with the pathological grade and clinical stage of prostate cancer, so as to determine the reference range of percent tPSA in Chinese men. Methods A total of 829 men （including 775 men without prostate disease and 54 with prostate cancer） were enrolled into the study and the serum PSA and tPSA levels were measured for calculating the percent tPSA. The 775 prostate disease-free subjects were divided into 5 age groups to study the relations of PSA, tPSA and percent tPSA with age. In the 54 patients with prostate cancer, the relations of pathological grade and clinical stage with percent tPSA were investigated with reference to the related data of the men without prostate disease to establish the appropriate reference range of percent tPSA for Chinese men. Results Serum PSA or tPSA levels, but not the percent tPSA, were correlated to age. In patients with prostate cancer, the percent tPSA was also correlated to the pathological grade and clinical stage. Among the men without prostate disease we investigated, the percent tPSA was significantly lower than that reported in other countries. The reference range of percent tPSA for Chinese men was≥15%. Conclusions The percent tPSA is not correlated to age and has greater clinical value than PSA measurement in the detection of prostate cancer. The percent tPSA decreases in prostate cancer patients with lowered pathological grade, advanced clinical stage, and therefore increased malignancy. The reference range of percent t^SA reported in other countries does not apply to Chinese men, and according to out investigation, the reference range of percent fPSA≥15% is appropriate for Chinese men.

关 键 词：游离前列腺特异性抗原百分比 前列腺癌 年龄 相关性 前列腺疾病 

分 类 号：R446.6[医药卫生—诊断学]