肺炎支原体感染及IL-6与哮喘急性发作关系的临床研究  

Clinical investigation on correlation of mycoplasma pneumoniae and IL-6 with acute episoded asthma

作　　者：乔永贤[1] 李炳植[1] 方英莲[1] 

机构地区：[1]延边第二人民医院儿科,吉林延吉133001

出　　处：《吉林医学》2008年第3期202-203,共2页Jilin Medical Journal

摘　　要：目的:研究肺炎支原体感染及IL-6与哮喘急性发作的关系。方法:选择哮喘急性发作患儿31例,肺炎患儿34例,健康儿童30例。采用①酶联免疫吸附试验(ELISA)法检测血清中MP-IgG、MP-IgM特异性抗体;②聚合酶链式反应(PCR)检测MP;③细胞因子(CK)检测ELISA法检测血清中IL-6。结果:①哮喘急性发作及肺炎患儿血清MP-IgG、MP-IgM检测:哮喘组用PCR法或IgM法检测MP阳性率高于肺炎组,差异有统计学意义(P<0.05),两组MP-IgG阳性率差异无统计学意义(P>0.05)。②哮喘及肺炎组患儿血清IL-6高于健康对照组,差异有统计学意义(P<0.01),而IL-6在哮喘及肺炎组间差异无统计学意义(P>0.05)。③两组MP及其特异性抗体检测一致性比较,差异无统计学意义(P>0.05)。结论:MP急性感染可能是哮喘急性发作的病原之一,IL-6与MP感染的发病密切相关,所以治疗的关键是控制和消除肺炎支原体感染。Objective To investigate the corelation of mycoplasma pneumoniae （MP） and IL -6 with acute episoded asthma. Method For 31 children with acute episoded asthma, 34 with pneumonia and 30 healthy ones were chosen. （1）Serum MP - IgG, MP - IgM were detected with ELISA. （2）MP were detected with PCR. （3）Serum IL - 6 were detected with CK - ELISA. Results （1）Detection of MP - IgG, MP - IgM in the serum of acute episoded asthma patients and pneumonia patients ： The positive rate of the asthma group was higher than that of the pneumonia group with the method of PCR or IgM, and had significant difference （P 〈 0.05 ） ; the positive rate of MP - IgG between the two groups showed no significant difference （ P 〉 0.05 ）. （2）The serum levels of IL - 6 in the asthma group and the pneumonia group were higher than that of the healthy group, and had significant difference （P 〈0.01 ） ,but IL -6 level between the asthma group and the pneumonia group had no significant difference（ P 〉 0.05）. （3）MP and concordance of it＇s special antibody between the two groups had no significant difference （P 〉 0.05 ）. Conclusion Acute infection of MP may be one of the pathogenies of acute episoded asthma, and IL- 6 has close correlation with MP infection, so controlling and eliminating MP infection is important.

关 键 词：哮喘急性发作 肺炎支原体 白细胞介素-6 

分 类 号：R725.6[医药卫生—儿科]