乘方相似度法定性定量评价银杏叶提取物HPLC指纹图谱  

Qualitative and quantitative assessment on the HPLC fingerprint of Ginkgo biloba L.extract by the involution similarity

作　　者：孙国祥[1] 史香芬[1] 毕雨萌[1] 刘金丹[1] 

机构地区：[1]沈阳药科大学药学院,辽宁沈阳110016

出　　处：《中成药》2008年第2期157-160,共4页Chinese Traditional Patent Medicine

基　　金：国家自然科学基金重大研究计划项目(No.90612002)

摘　　要：目的:建立中药色谱指纹图谱乘方相似度和定量乘方相似度评价方法及其应用。方法:用乘方相似度和定量乘方相似度评价银杏叶提取物HPLC指纹图谱,并以夹角余弦SF、相关系数r和描述定量特征的指标即宏观含量相似度R%、平均质量百分数M%进行对比研究。结果:乘方相似度能够反映不同批次提取物的相似性变化,并具有定量描述功能:定量乘方相似度和加权定量乘方相似度能够较好地反映提取物不同成分含量的宏观变化。结论:乘方相似度和定量乘方相似度能够定性定量评价样品与对照指纹图谱间的相似程度,是一种新的相似度评价方法。AIM ： To establish the assessing method of traditional Chinese medicine chromatogrphic fingerprints by the involution similarity and quantitative involution similarity and its application. METHODS： The fingerprint of Ginkgo biloba L. extract （GBE） was evaluated by the involution similarity and quantitative involution similarity, and the contrast studies were implemented by other appraisal targets, eg. the included angle cosine SF, the correla- tion coefficient r and the indexes with quantitative characteristic, such as the apparently quantitative similarity R%, the average mass percent M%, etc.. RESULTS： The involution similarity could reflect the similarity change in each sample from different bathes and be of quantitative function. The quantitative involution similarity and quantitative weighted similarity could perfectly reflect the changes in contents of the consituents of GBE. CONCLUSION： The involution similarity and quantitative involution similarity can qualitatively and quantitatively assess the similarity between sample and the referential fingerprint. They are certainly the novel method of evaluating the traditional Chinese medicine chromatographic fingerprints.

关 键 词：乘方相似度 定量乘方相似度 银杏叶提取物 HPLC指纹图谱 

分 类 号：R284.1[医药卫生—中药学]