2-(3-芳氧甲基-4-苯基-1,2,4-三唑-5-硫基)乙酸的微波合成及生物活性研究  

Synthesis and Biological Activity of 2-(3-Phenoxymethyl-4-phenyl-1,2,4triazole-5-thio)acetic Acid

作　　者：王良成[1] 唐静[1] 魏太保[1] 张有明[1] 

机构地区：[1]西北师范大学化学化工学院甘肃省高分子重点实验室,兰州730070

出　　处：《有机化学》2008年第2期343-347,共5页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.20671077);教育部科学技术研究重点(No.205161);甘肃省中青年科学基金(No.3ZS041-A25-007)资助项目

摘　　要：在微波辐射条件下,芳氧乙酰肼经两步反应制得4-苯基-3-芳氧甲基-1,2,4-三唑-5-硫酮衍生物,再与氯乙酸反应得到6种尚未见文献报道的2-(3-芳氧甲基-4-苯基-1,2,4-三唑-5-硫基)乙酸衍生物.目标化合物的结构经IR,1HNMR和元素分析进行了确证.生物活性试验结果表明,该类化合物对双子叶植物油菜具有良好的生物调节活性.Six derivatives of 4-phenyl-3-phenoloxymethyl-5-mercapto-l,2,4-triazlyole were synthesized from phenoloxyacetyl hydrazide by two-steps reaction under microwave irradiation, then reacted with 2-chloroacetic acid to give six novel derivatives of 2-（3-phenoxymethyl-4-phenyl-[1,2,4]triazole-5-thio）- acetic acid. All the products were characterized by elemental analysis, FT-IR and 1H NMR spectra. The preliminary biological activity tests showed that all the compounds have obvious regulating activities for the growth of cole.

关 键 词：2-(3-芳氧甲基-4-苯基-1 2 4-三唑-5-硫基)乙酸 生物活性 微波合成 三唑 

分 类 号：TQ252.6[化学工程—有机化工]