豚鼠组织中缩醛磷脂酰乙醇胺生物合成能力的比较  

Biosynthesis power of phosphatidal- ethanolamine in guinea pig tissues

作　　者：吕俊[1] 吕灿群[1] 

机构地区：[1]皖南医学院生物化学教研室,安徽芜湖241002

出　　处：《皖南医学院学报》2008年第1期16-17,21,共3页Journal of Wannan Medical College

基　　金：安徽省教育厅自然科学研究基金项目(97JL158)

摘　　要：目的:探讨豚鼠不同组织中缩醛磷脂酰乙醇胺生物合成能力及其生理意义。方法:使用[3H]-乙醇胺作为原料物,经腹膜内注射至豚鼠体内,检查该标记物在含乙醇胺的缩醛磷脂中在不同组织内的合成能力。结果:显示标记乙醇胺进入缩醛磷脂的能力具有组织特异性,在心脏和大脑中合成能力最强,分别占41%和40%,肾脏居中,占25%。合成能力最低的是肝脏,仅占9%。结论:心脏和大脑是合成缩醛磷脂酰乙醇胺的主要器官,这与它们的重要生理功能相吻合。Objective ：To approach the biosynthesis power of phosphatidat-ethanolamine in guinea pig tissues for physiological studies. Mahods ：Experimental guinea pigs were injected interperitoneally with [^3H]-ethanolamine for exploring biosynthesis power by detecting phosphatidal-ethanolamine-contained label in different tissues. Results：The results revealed that labeling ethanolamine into phosphatidalethanolamine demonstrated specificity in tissues. The biosynthesis power in heart and brain was prominent （41% and 40% respectively） and followed by kidney tissues （25 % ）, less power was seen in liver tissues with a percentage of 9%. Conclusion ：The heart and brain were central organs in biosynthesis of phosphatidal-ethanolamine, which is identical with their important physiological function.

关 键 词：乙醇胺 缩醛磷脂酰乙醇胺 生物合成 豚鼠 

分 类 号：R344.52[医药卫生—基础医学]