NT-proBNP在急性冠脉综合征中的研究  

Study on the Changes of Serum NT-proBNP Levels in Patients with ST Elevation and Non-ST Elevation Acute Coronary Syndrome

作　　者：赵世平[1] 曹秀华[1] 张丽娜[1] 

机构地区：[1]大庆油田总医院检验科,163001

出　　处：《放射免疫学杂志》2008年第1期79-82,共4页Journal of Radioimmanology

摘　　要：目的:N端脑钠素前体(N-terminal pro-B-type natriuretic peptide,NT-proBNP)在ST抬高型急性冠脉综合征(STelevation acute coronary syndrome,STE-ACS)及非ST抬高型急性冠脉综合征(non-STelevationacute coronary syndrome,NSTE-ACS)中比较分析。方法:62名伴有急性胸痛和诊断非稳定绞痛或急性心肌梗死的患者(>killip II型以上患者排除在外),分别测定NT-proBNP、肌酸激酶-MB(creatine kinase-MB,CK-MB)、心肌钙蛋白I(troponin I,TnI)。结果:CK-MB,及TnI在STE-ACS患者中明显高于NSTE-ACS,相反,NTpro-BNP在NSTE-ACS中明显高于STE-ACS患者,尤其在疾病发作3h内。结论:NT-proBNP是心肌缺血的早期诊断标志物,它在心肌损伤的早期就明显升高,尤其是在NSTE-ACS患者中。Objective To study the changes of serum levels of NT - proBNP and conventional cardiac markers （ CK - MB, TnI） in patients with ST eveation and non - STE ACS. Methods Serum NT - proBNP （ with ECLIA）, CK - MB （ with enzyme dynamic method） and TnI （ with ECLIA） levels were measured in 28 patients with STE - ACS and 34 patients with NSTE - ACS. Results Serum CK- MB and TnI levels were both significantly higher in STE- ACS patients than those in patients with NSTE -ACS. However, serum NT - proBNP levels were significantly higher in NSTE - ACS patients than those in patients with STE - ACS, especially within the 1st 3hs after onset. Conclusion NT - proBNP is an early sensitive marker of myocardial ischemia which rises much earlier in NSTE - ACS patients.

关 键 词：N端脑钠素前体 ST抬高型急性冠脉综合征 非ST抬高型急性冠脉综合征 

分 类 号：R543.3[医药卫生—心血管疾病] R541.4[医药卫生—内科学]