畅脉舒对高脂喂养家兔内皮依赖性舒张的保护作用  

EFFECT OF CHANGMAISHU ON ENDOTHELIUM DEPENDENT RELAXATION IN RABBIT FED WITH CHOLESTEROL

作　　者：宋秀媛[1] 王家富[1] 姜波[1] 刘同美[1] 段文卓[1] 王建英[1] 丁怡[1] 

机构地区：[1]潍坊医学院病理生理学教研室应用药理学实验室

出　　处：《潍坊医学院学报》1997年第3期170-171,共2页Acta Academiae Medicinae Weifang

摘　　要：目的观察抗动脉粥样硬化复方制剂畅脉舒对高胆固醇喂养家兔肾动脉、髂动脉内皮依赖性舒张的作用。方法实验分为对照组、高胆固醇组、畅脉舒组和去内皮组，比较各组动脉环对去甲肾上腺素、乙酰胆碱及硝普钠的反应。结果高脂组内皮依赖性舒张作用显著降低，畅脉舒组虽低于对照组但显著高于高脂组，正常对照组、高脂组及畅脉舒组对去甲肾上腺素的收缩反应及对硝普钠的舒张反应差异无显著性。肾动脉和髂动脉结果相似。结论畅脉舒对高胆固醇喂养家兔肾动脉、髂动脉的内皮依赖性舒张具有保护作用。Objective To determine the effect of Changmaishu(CMS) on the loss ofendothelium dependent relaxation(EDR) of the renal and iliac artery in rabbits fed with cholesternol (0.5g per day).Method There are four groups in this experiment including control group,hypercholesterol (HC) group,HC+CMS group and endothelium removed(-End) group.EDR to acetylcholine(Ach),contractile responses to noradrenaline,and relaxation to sodiumnitroprusside (Nit)in the renal and iliac arteries were studied.Result EDR to Ach in CMS group is significantly greater than in HC group ( P<0.01). There are no differences in the contraction elicited by NE and the relaxant responses to Nit.Conclusion CMS protects the renal and iliac arteries from the loss of EDR in rabbits fed with cholestrol.

关 键 词：内皮依赖性舒张 肾动脉 髂动脉 畅脉舒 药理 

分 类 号：R972[医药卫生—药品] R965.2[医药卫生—药学]