联合免疫预防乙型肝炎病毒父婴传播的初步研究  

Combined vaccination with immunoglobulin in prevention of vertical transmission of HBV from father to baby

作　　者：夏良斌[1] 蒋蕾[1] 李爱斌[1] 杨菁[1] 徐望明[1] 

机构地区：[1]武汉大学人民医院生殖中心,430060

出　　处：《中华全科医师杂志》2008年第3期181-182,共2页Chinese Journal of General Practitioners

基　　金：湖北省自然科学基金项目（2007ABA232）,湖北省计划生育委员会资助项目（302140623）

摘　　要：研究对象来自2003年5月至2006年5月在我院产科就诊的405例孕妇，其丈夫均为HBsAg、HBeAg、抗-HBc阳性，采用完全随机实验设计方法将218例抗-HBs阳性孕妇分为A组和B组，187例抗-HBs阴性孕妇作为C组，A、C组孕妇产前肌内注射乙型肝炎免疫球蛋白。结果新生儿宫内感染率A组12．1％，B组12．8％，C组23．0％。Four hundred and five pregnant women whose husbands had positive HBeAg, HBsAg and antiHBc were recruited in the study. Among them, 218 women with positive HBsAb were completely randomized into group A and group B, while 187 cases with negative HBsAb formed group C. Women in group A and group C were injected with hepatitis B immunoglobulin （HBIG） before delivery. All newborn babies in 3 groups received routine HCV vaccination, in addition babies in group A and group C also received HBIG injection within 24 h after birth. The HBV infection rate of newborns was 12. 1% in group A, 12. 8% in group B and 23.0% in group C respectively.

关 键 词：乙型肝炎病毒 接种 父婴传播 疾病预防 

分 类 号：R51[医药卫生—内科学]