血浆纤维蛋白原与冠状动脉粥样硬化性心脏病的相关性研究  

Relationship between Plasma Fibrinogen Level and Coronary Heart Disease

作　　者：李丽[1] 高大胜[1] 

机构地区：[1]安徽省蚌埠医学院第一附属医院心血管科,233004

出　　处：《实用全科医学》2008年第3期228-229,共2页Applied Journal Of General Practice

摘　　要：目的探讨冠状动脉粥样硬化性心脏病(简称冠心病,Coronary heart disease, CHD)患者血浆纤维蛋白原(Fi-brinogen,Fg)水平变化与冠状动脉病变程度和不同类型冠心病的关系。方法101例CHD患者[其中单支血管病变组46例,双支血管病变组30例,多支血管病变组25例;不稳定性心绞痛(UAP)62例,急性心肌梗死(AMI)28例,稳定性心绞痛(SAP)11例]与37例对照组,采集静脉血,检测血浆Fg等水平,然后进行统计学处理。结果CHD组血浆Fg[(3.75640±1.15034)g/L]均较对照组Fg[(2.85140±0.64145)g/L]显著升高(P<0.001);并且按冠状动脉病变支数分组后,多支病变组血纤维蛋白原高于单支病变组(P<0.05),按疾病类型分组后AMI组血纤维蛋白原均高于UAP组和SAP组(P<0.05)。结论血纤维蛋白原在冠心病的发病机制中可能起一定作用,可以作为预测急性心肌梗死和判断冠脉病变严重程度的参考指标。Objective To Study on relationship between change of plasma fibrinogen and coronary heart disease. Methods The levels of plasma fibrinogen were measured in 101 patients with coronary heart disease（ CHD）, and compared with 37 normal subjects. Results Plasma fibrinogen （3. 75640 ± 1. 15034） g/L levels of CHD patients were significantly higher than normal subjects＇ Fg （2.85140 ± 0. 64145 ） g/L（P 〈 0. 001 ）. Compared with that in the single-vessel lesion group,the level of fibrinogen in triple-vessel group was higher （ P 〈 0.05 ）. The concentration of fibrinogen in patients with acute myocardial infarction （AMI） group was significantly higher than that in patients with unstable angina pectoris（UAP） group and stability angina pectoris（SAP） group（P〈O. 05）. Conclusions Plasma fibrinogen may he associated with CHD. There was obviously correlation in the level of plasma fibrinogen and severity of coronary artery disease.

关 键 词：血浆纤维蛋白原 冠状动脉粥样硬化性心脏病 

分 类 号：R541.4[医药卫生—心血管疾病]