基因芯片在白念珠菌耐药基因研究中的应用  

Application of gene chip technique in studying drug resistance genes in Candida albicans

作　　者：麻志萍[1] 原永芳[1] 贾鑫明[2] 王彦[2] 曹永兵[2] 付守廷[3] 姜远英[2] 

机构地区：[1]上海交通大学医学院附属第三人民医院药剂科,上海201900 [2]第二军医大学药学院药理学教研室,上海200433 [3]沈阳药科大学药理教研室,沈阳010016

出　　处：《第二军医大学学报》2008年第2期211-214,共4页Academic Journal of Second Military Medical University

摘　　要：近年来,临床上白念珠菌耐药现象日趋增多,利用基因芯片来绘制基因表达图谱是目前研究白念珠菌耐药基因最常用的手段。通过基因芯片对菌株在不同药物处理或经不同途径产生耐药表型后大量差异表达基因进行分析,可用来寻找耐药相关基因,并阐明其功能,更有助于多基因协同作用机制的深入研究。In recent years, drug resistance of Candida albicans is on a rise in clinical practice. Gene chip technique is the most commonly used means to map gene expression profile in drug resistant Candida albicans. Gene chip can be used to analyze the differentially expressed genes in drug resistant Candida albicans strains induced by various procedures. The drug resistant genes can be identified and their functions can be further studies. The results of gene chip study can also play a role in studying the mechanism of synergism of multiple drug resistance genes.

关 键 词：白念珠菌 耐药相关基因 寡核苷酸序列分析 

分 类 号：R379.4[医药卫生—病原生物学]