牙周基础治疗对2型糖尿病患者糖脂代谢的影响  

The effect of initial periodontal therapy on metabolic control in type 2 diabetes mellitus

作　　者：沈弛晶[1] 尹元正[1] 束蓉[1] 

机构地区：[1]上海交通大学医学院附属第九人民医院·口腔医学院牙周病科,上海市口腔医学研究所,上海200011

出　　处：《上海口腔医学》2008年第1期6-9,共4页Shanghai Journal of Stomatology

基　　金：科技部“十五”攻关课题(2004BA720A26)

摘　　要：目的:观察伴发2型糖尿病的慢性牙周炎患者的牙周状况,探讨牙周基础治疗对牙周状况及糖脂代谢的影响。方法:选择伴发2型糖尿病的慢性牙周炎患者30例,非糖尿病慢性牙周炎患者30例,分析治疗前及治疗后1、3个月的牙龈指数、牙周探诊深度、附着丧失水平以及糖化血红蛋白、甘油三酯、总胆固醇水平。研究数据采集完成后,以SAS6.12软件包对结果进行双因素方差分析。结果:牙周治疗后,患者的牙周状况均有改善,差异有显著性(P<0.05)。血糖控制欠佳的患者,治疗后糖化血红蛋白有所改善,差异有显著性(P<0.05);而血糖控制较好者,其糖化血红蛋白治疗后下降不明显。基础治疗对患者的血脂水平无显著影响。结论:伴发2型糖尿病的慢性牙周炎患者接受基础治疗后,短期效果良好;血糖控制欠佳的患者,基础治疗有助其糖代谢水平的改善,但血糖控制良好者,基础治疗对其糖代谢水平无显著影响。PURPOSE： To investigate the effect of periodontal initial therapy on metabolic control in type 2 diabetes mellitus patients with chronic periodontitis. METHODS： Thirty type 2 diabetic patients with chronic periodontitis were selected as experimental group, 30 patients with chronic periodontitis were selected as control group. Their gingival index （GI）, probing depth（PD）, clinical attachment level（CAL）, fasting plasma glucose（FPG）, glycated hemoglobin Alc（HbAlc）, total cholesterol（TC） and triglyceride（TG） were evaluated using SAS 6.12 software package for multiple linear regression analysis before treatment（as base） and 1, 3 month（s） after periodontal initial therapy. RESULTS： In both two groups, a significant improvement of periodontal index was found after periodontal initial therapy （P〈0.05）. After therapy, TC, TG in diabetic patients showed no changes （P〉0.05）, and FPG, HbAlc in fairly-controlled diabetic patients were reduced significantly （P〈0.05） whereas the well-controlled diabetic patients showed slight but insignificant decrease for these parameter（P〉0.05）. CONCLUSION： The result of periodontal initial therapy in the type 2 diabetic patients with chronic periodontitis is significant in short time. It can reduce the level of FPG and HbAlc.

关 键 词：慢性牙周炎 2型糖尿病 糖脂代谢 牙周基础治疗 

分 类 号：R587.1[医药卫生—内分泌] R781.4[医药卫生—内科学]